Transmission of non-A non-B hepatitis to chimpanzees by factor-IX concentrates after fatal complications in patients with chronic liver disease
| Autor: | R J Wyke, Bernard Portmann, K. N. Tsiquaye, Y.S. White, P. K. Das, Roger Williams, A. J. Zuckerman, Anthea Thornton |
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| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Hepatitis Viral Human Pan troglodytes Congenital cytomegalovirus infection Chronic liver disease Gastroenterology Virus Factor IX Liver Function Tests Internal medicine medicine Animals Humans Aged Hepatitis medicine.diagnostic_test business.industry Transmission (medicine) Hepatitis A Transfusion Reaction General Medicine Middle Aged medicine.disease Liver Liver biopsy Hepatitis Viral Animal Immunology Acute Disease Female business Drug Contamination medicine.drug |
| Zdroj: | Lancet (London, England). 1(8115) |
| ISSN: | 0140-6736 |
| Popis: | 6 cases of non-A non-B hepatitis which followed administration of four different batches of concentrates of coagulation factor IX from commercial and non-commercial sources are described. Of 17 patients who received the concentrate on account of chronic liver disease, 4 developed hepatitis, and in 3 of these the illness proved fatal. The incubation periods ranged from 42 to 103 days (mean 65 days). 3 chimpanzees were inoculated with concentrate from the same batch used on the above patients, a further commercial batch upon which no adverse reactions had been reported, and plasma from a known non-A non-B carrier. All developed hepatitis after 10 weeks' incubation. Liver biopsy when serum-aminotransferase was at its highest level showed features consistent with acute hepatitis. As in the patients, viral markers for hepatitis A and B, cytomegalovirus, and Epstein-Barr virus were unchanged. |
| Databáze: | OpenAIRE |
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