Metabolic Alteration and Amyotrophic Lateral Sclerosis Outcome: A Systematic Review
| Autor: | Beatriz Grisolia Araujo, Mariana Dutra Brito, Tatiana R. Rosenstock, Erick Mutti Tilieri, Gustavo Ferro Gomes da Silva, Michele Longoni Calió |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty amyotrophic lateral sclerosis Web of science Degenerative Disorder Disease outcome patients lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine systematic review Diabetes mellitus medicine Amyotrophic lateral sclerosis Intensive care medicine prognostic factor lcsh:Neurology. Diseases of the nervous system Disease prognosis business.industry medicine.disease Obesity 030104 developmental biology Neurology Hypermetabolism Neurology (clinical) business metabolism 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Neurology Frontiers in Neurology, Vol 10 (2019) |
| ISSN: | 1664-2295 |
| Popis: | Background: The development of strategies that could not only efficiently detect the onset of Amyotrophic Lateral Sclerosis (ALS), a fatal neurodegenerative disorder with no cure but also predict its development and evaluate therapeutic intervention would be of great value. In this respect, the metabolic status of ALS patients has called attention. Hence, this study aimed to investigate the potential correlation between changes in ALS's metabolic parameters with the disease outcome in a systematic review.Methods: The manuscripts were manually searched within different databases (PubMed, Web of Science and Cochrane). The inclusion criteria were original articles and reviews about individuals with ALS and its survival, disease prognosis and metabolism (weight, cholesterol, hypertension, BMI, and glycaemia). The authors also established three different exclusion criteria: studies including ALS and other degenerative disorders, works including animal models and published before the year 2000.Results: In total, 29 papers were selected. From all manuscripts, only 82.8% ensured the participation of sALS patients. Also, 27.6% of selected studies described the presence of a genetic mutation. Regarding ALS prognosis, patient's age, the age of ALS onset, ALS duration and survival |
| Databáze: | OpenAIRE |
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