Early-generated interneurons regulate neuronal circuit formation during early postnatal development
| Autor: | Shao-Na Jiang, Lin-Yun Liu, Shu-Qing Zhang, Ye-Qian Xu, Yong-Chun Yu, Yinghui Fu, Jian Ma, Chang-Zheng Wang, Zu-Liang Yuan, Xiao-Yi Mao, Tian-Qi Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Mouse QH301-705.5 Science Cell Biology Neurotransmission Inhibitory postsynaptic potential Somatosensory system General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences 0302 clinical medicine Interneurons Fate mapping medicine Animals synaptic transmission neocortical synchronized activity Biology (General) development Neocortex General Immunology and Microbiology General Neuroscience early-generated interneurons Somatosensory Cortex General Medicine Electrophysiology 030104 developmental biology medicine.anatomical_structure Animals Newborn nervous system Medicine Nerve Net Neuroscience 030217 neurology & neurosurgery Research Article |
| Zdroj: | eLife, Vol 8 (2019) eLife |
| Popis: | A small subset of interneurons that are generated earliest as pioneer neurons are the first cohort of neurons that enter the neocortex. However, it remains largely unclear whether these early-generated interneurons (EGIns) predominantly regulate neocortical circuit formation. Using inducible genetic fate mapping to selectively labeled EGIns and pseudo-random interneurons (pRIns), we found that EGIns exhibited more mature electrophysiological and morphological properties and higher synaptic connectivity than pRIns at early postnatal stages. In addition, when stimulating one cell, the proportion of EGIns that influence spontaneous network synchronization is significantly higher than that of pRIns. Importantly, toxin-mediated ablation of EGIns after birth significantly reduce spontaneous network synchronization and decrease inhibitory synaptic transmission during the first postnatal week. These results suggest that EGIns can shape developing networks and may contribute to the refinement of neuronal connectivity before the establishment of the adult neuronal circuit. |
| Databáze: | OpenAIRE |
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