High prevalence of antibodies against hepatitis E virus in HIV-infected patients with unexplained liver disease
| Autor: | Loreto Martinez-Dueñas, Juan A. Pineda, Elisabet Pérez-Navarro, Antonio Rivero, Nicolás Merchante, Angela Camacho, Manuel Parra-Sánchez, Antonio Rivero-Juárez, Celia Cifuentes, Juan Macías |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Microbiology (medical) Cirrhosis viruses Immunoblotting Enzyme-Linked Immunosorbent Assay HIV Infections Real-Time Polymerase Chain Reaction medicine.disease_cause Liver disease Hepatitis E virus Seroepidemiologic Studies Humans Medicine Hiv infected patients Hepatitis Antibodies Chronic hepatitis E High prevalence biology business.industry virus diseases RNA Middle Aged medicine.disease Virology Elasticity digestive system diseases Hepatitis E Liver Case-Control Studies Immunology biology.protein RNA Viral Female Antibody business |
| Zdroj: | Enfermedades Infecciosas y Microbiología Clínica. 33:532-535 |
| ISSN: | 0213-005X |
| Popis: | Objective To look for evidence of hepatitis E virus (HEV) exposure in HIV-infected patients with unexplained elevations of liver stiffness (LS). Methods Case–control study conducted in 31 HIV-infected patients with unexplained elevations of LS and in 31 HIV-controls with normal LS, matched by age, sex and CD4 cell-counts. Serum HEV antibodies were tested by two ELISA procedures and by Immunoblot. We defined exposure to HEV as the detection of serum HEV antibodies by at least one of the two ELISA assays, provided that it was confirmed by Immunoblot. A real-time PCR RNA assay was conducted in all plasma samples to identify subjects with active HEV infection. Results Exposure to HEV was demonstrated, according to the criteria used in this study, in 9 (29%) of the cases, whereas it was shown in 5 (16%) of the controls ( p = .3). Serum HEV RNA was detected in none of the controls and in only in one case. This patient had a documented chronic hepatitis E with progression to cirrhosis. Conclusions HEV antibodies are frequently found in HIV-infected patients with unexplained liver disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|