Prediction of outcome in buccal cancers treated with radical radiotherapy based on the early tumor response
| Autor: | Thejaswini B, Aradhana K, G.V. Giri, R Nanda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Brachytherapy Tumor response Buccal mucosa lcsh:RC254-282 Disease-Free Survival Young Adult medicine Carcinoma Humans interstitial implant Radiology Nuclear Medicine and imaging Clinical significance Aged tumor response business.industry Mouth Mucosa oral cavity cancers Radical radiotherapy Radiotherapy Dosage General Medicine Buccal administration prediction Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Surgery Radiation therapy Oncology outcome Female Mouth Neoplasms Radiology business |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 11, Iss 2, Pp 364-368 (2015) |
| ISSN: | 1998-4138 0973-1482 |
| Popis: | Aim of the Study: Aim was to assess the clinical significance of the rate of tumor regression in carcinoma buccal mucosa undergoing radical radiotherapy. Materials and Methods: Sixty six patients were enrolled in the study with proven buccal cancers requiring radical radiotherapy, from 1990 to 1996. Radiotherapy was delivered using a combination of external beam and brachytherapy with preloaded cesium 137 needles. The response to the radiation was assessed at the completion of external beam radiation and 6 weeks after brachytherapy. An analysis correlating various parameters influencing the long term disease free survival and overall survival was done. Results: Response assessed at the end of external beam radiation correlated strongly with the overall survival and the disease free interval (P=0.000). No other factor influenced the survival. Conclusion: The rate of the tumor regression can predict the overall outcome in patients with buccal cancers treated with radiation. Completion of the planned course of radiation in patients who do not show a substantial reduction in size by 4.5 weeks of conventional radiation does not improve the results. |
| Databáze: | OpenAIRE |
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