Comparison of betaxolol, a new beta 1-adrenergic antagonist, to propranolol in the treatment of mild to moderate hypertension
| Autor: | Phillip G. Zager, Jose L. Cangiano, Michael E. Davidov, Norman Glazer, Gary L. Wollam |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Supine position Adrenergic beta-Antagonists Propranolol Essential hypertension Betaxolol Propanolamines Heart Rate Heart rate Internal Medicine medicine Adrenergic antagonist Humans Systole Aged Clinical Trials as Topic business.industry Middle Aged medicine.disease Blood pressure Anesthesia Hypertension Female business medicine.drug |
| Zdroj: | American journal of hypertension. 1(3 Pt 3) |
| ISSN: | 0895-7061 |
| Popis: | A double-blind, multicenter study compared the safety and efficacy of oral betaxolol 10 to 40 mg once daily (n = 68) with propranolol 40 to 160 mg twice daily (n = 73) in the treatment of mild to moderate essential hypertension. Both agents produced significant (P less than 0.01) and comparable reductions in mean supine systolic and diastolic blood pressures (7/11 mm Hg on betaxolol and 9/10 mm Hg on propranolol). Both betaxolol and propranolol significantly (P less than 0.01) reduced mean supine heart rate by 9 beats per minute. Patients achieved a more significant (P less than 0.01) reduction in blood pressure earlier (weeks 2 and 4 of the titration period) with betaxolol. By the end of treatment there was no significant difference in response between treatment groups. A higher incidence of central nervous system side effects (insomnia, bizarre dreams, depression, hallucinations, dizziness), however, was seen with propranolol than with betaxolol. Overall, the data show that in patients with mild to moderate essential hypertension, betaxolol 10 to 40 mg administered once daily is as effective as and better tolerated than propranolol 40 to 160 mg administered twice daily. |
| Databáze: | OpenAIRE |
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