Thin TiO2Coatings by ALD Enhance the Cell Growth on TiO2Nanotubular and Flat Substrates
| Autor: | Pavlina Majtnerova, Jan M. Macak, Tomáš Roušar, Kaushik Baishya, Jan Capek, Zdenek Spotz, Martin Motola, Jan Prikryl, Hanna Sopha, Petr Knotek, Jana Bacova, Ludek Hromadko, Raul Zazpe, Lenka Bruckova, Jiri Handl, Siowwoon Ng |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
TiO2 nanotube layers Tio2 nanotube Biochemistry (medical) Biomedical Engineering Oxide Ti sheets General Chemistry coatings musculoskeletal system Biomaterials Atomic layer deposition chemistry.chemical_compound Chemical engineering chemistry atomic layer deposition cell growth Layer (electronics) |
| Zdroj: | ACS Applied Bio Materials. 2020, vol. 3, issue 9, p. 6447-6456. |
| Popis: | The present work exploits Ti sheets and TiO2 nanotube (TNT) layers and their surface modifications for the proliferation of different cells. Ti sheets with a native oxide layer, Ti sheets with a crystalline thermal oxide layer, and two kinds of TNT layers (prepared via electrochemical anodization) with a defined inner diameter of 12 and 15 nm were used as substrates. A part of the Ti sheets and the TNT layers was additionally coated by thin TiO2 coatings using atomic layer deposition (ALD). An increase in cell growth of WI-38 fibroblasts (>50%), MG-63 osteoblasts (>30%), and SH-SY5Y neuroblasts (>30%) was observed for all materials coated by five cycles ALD compared to their uncoated counterparts. The additional ALD TiO2 coatings changed the surface composition of all materials but preserved their original structure and protected them from unwanted crystallization and shape changes. The presented approach of mild surface modification by ALD has a significant effect on the materials’ biocompatibility and is promising toward application in implant materials. |
| Databáze: | OpenAIRE |
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