Maternal resistin predisposes offspring to hypothalamic inflammation and body weight gain
| Autor: | Delphine Crépin, Yacir Benomar, Ghislaine Poizat, Laure Riffault, Sarah Al Rifai, Mohammed Taouis, Coralie Alexandre |
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| Přispěvatelé: | Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Leptin
Male 0301 basic medicine endocrine system diseases Physiology Peptide Hormones medicine.medical_treatment [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Adipose tissue Pathology and Laboratory Medicine Weight Gain Biochemistry Mice Endocrinology 0302 clinical medicine Pregnancy Medicine and Health Sciences Insulin Resistin Immune Response Multidisciplinary [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior Brain [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Physiological Parameters Adipose Tissue Medicine Female Anatomy Inflammation Mediators medicine.symptom hormones hormone substitutes and hormone antagonists Research Article medicine.medical_specialty Offspring Science Inflammatory Diseases Immunology Hypothalamus 030209 endocrinology & metabolism Inflammation Weaning 03 medical and health sciences Signs and Symptoms Insulin resistance Diagnostic Medicine Internal medicine Glucose Intolerance medicine Animals Lactation Obesity Diabetic Endocrinology Leptin receptor business.industry Body Weight Biology and Life Sciences nutritional and metabolic diseases Maternal Nutritional Physiological Phenomena medicine.disease Hormones Biological Tissue 030104 developmental biology Animals Newborn Insulinoma Insulin Resistance business Hormone |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2019, 14 (3), pp.e0213267. ⟨10.1371/journal.pone.0213267⟩ PLoS ONE, Vol 14, Iss 3, p e0213267 (2019) |
| ISSN: | 1932-6203 |
| Popis: | International audience; Resistin promotes hypothalamic neuroinflammation and insulin resistance through Toll like receptor 4 (TLR4), this hormone is thought to be a link between obesity and insulin-resistance. Indeed, resistin plasma levels are higher in obese and insulin resistant subjects. However, the impact of maternal resistin on the predisposition of offspring to hypothalamic neuroinflammation is unknown. Here, female mice were treated with resistin during gestation/lactation periods, then hypothalamic neuroinflammation was investigated in male offspring at p28 and p90. At p28, resistin increased the expression of inflammation markers (IL6, TNFα and NFκB) and TLR4 in the hypothalamus and decreased both hypothalamic insulin and leptin receptors' expression. The hypothalamic up-regulation IL6, TNFα and TLR4 was sustained until p90 promoting most likely hypothalamic inflammation. Maternal resistin also increased IL6 and TNFα in the adipose tissue of offspring at p90 associated with a higher body weight gain. In contrast, liver and muscle were not affected. These findings reveal that the augmentation of maternal resistin during gestation and lactation promotes hypothalamic and adipose tissue inflammation of offspring as evidenced by sustained increase of inflammation markers from weaning to adulthood. Thus, maternal resistin programs offspring hypothalamic and adipose tissue inflammation predisposing then offspring to body weight gain. |
| Databáze: | OpenAIRE |
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