Robocasting of Bioactive SiO2-P2O5-CaO-MgO-Na2O-K2O Glass Scaffolds
| Autor: | Gissur Örlygsson, Jacopo Barberi, Elisa Fiume, Jonathan Massera, Francesco Baino, Enrica Verne |
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| Přispěvatelé: | Tampere University, BioMediTech |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Medical technology
Materials science Article Subject Scanning electron microscope Simulated body fluid 0206 medical engineering Biomedical Engineering Biocompatible Materials Health Informatics 02 engineering and technology Materials Testing Mechanical strength Scaffold architecture Porosity Silicate glass lcsh:R5-920 Tissue Scaffolds Oxides 217 Medical engineering Poloxamer 021001 nanoscience & nanotechnology 020601 biomedical engineering Compressive strength lcsh:R855-855.5 Chemical engineering Surgery Glass lcsh:Medicine (General) 0210 nano-technology Research Article Biotechnology |
| Zdroj: | Journal of Healthcare Engineering, Vol 2019 (2019) Journal of Healthcare Engineering |
| ISSN: | 2040-2309 2040-2295 |
| DOI: | 10.1155/2019/5153136 |
| Popis: | Bioactive silicate glass scaffolds were fabricated by a robocasting process in which all the movements of the printing head were programmed by compiling a script (text file). A printable ink made of glass powder and Pluronic F-127, acting as a binder, was extruded to obtain macroporous scaffolds with a grid-like three-dimensional structure. The scaffold architecture was investigated by scanning electron microscopy and microtomographic analysis, which allowed quantifying the microstructural parameters (pore size 150–180 μm and strut diameter 300 μm). In vitro tests in simulated body fluid (SBF) confirmed the apatite-forming ability (i.e., bioactivity) of the scaffolds. The compressive strength (around 10 MPa for as-produced scaffolds) progressively decreased during immersion in SBF (3.3 MPa after 4 weeks) but remains acceptable for bone repair applications. Taken together, these results (adequate porosity and mechanical strength as well as bioactivity) support the potential suitability of the prepared scaffolds for bone substitution. |
| Databáze: | OpenAIRE |
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