GROWTH FAILURE WITH NORMAL SERUM RIA-GH AND LOW SOMATOMEDIN ACTIVITY: SOMATOMEDIN RESTORATION AND GROWTH ACCELERATION AFTER EXOGENOUS GH
| Autor: | Virginia V. Weldon, A.A. Kowarski, William H. Daughaday, Jochen G. Schneider, E. Ben-Galim |
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| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Radioimmunoassay Dwarfism Stimulation Normal serum Biochemistry Endocrinology Somatomedins Internal medicine medicine Laron syndrome Humans Growth Disorders business.industry Biochemistry (medical) medicine.disease Somatomedin Child Preschool Growth Hormone Normal growth business Hormone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 47:461-466 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Two three-year-old boys with dwarfism (height ages 1–4/12 and 1–11/12 years) and delayed bone ages (1–4/12 and 1–9/12 years) had normal growth hormone (GH) responses after stimulation and low levels of somatomedin. Unlike patients with Laron Syndrome, the two patients generated normal levels of somatomedin after administration of exogenous hGH. Treatment with hGH (2 IU every other day) brought about a significant increase in the growth rate of both patients. The growth rate of the first patient increased from 2 cm/year before treatment to 12 cm/year on therapy. The growth rate of the second patient was 4.5 cm/year before treatment, and 8.3 cm/year while on treatment. The two cases represent a new syndrome of dwarfism which may be caused by secretion of a biologically inactive but immunoreactive GH. |
| Databáze: | OpenAIRE |
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