Angiogenesis is an early event in the generation of myc-induced lymphomas
| Autor: | Alanna Ruddell, Kimberly A Brandvold, Paul E. Neiman |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Cancer Research
Lymphoma Angiogenesis Genes myc Chick Embryo Biology Bursa of Fabricius Tumor Cells Cultured Genetics medicine Animals Progenitor cell Molecular Biology B cell B-Lymphocytes Avian Leukosis Virus Neovascularization Pathologic Oncogene Cell Transformation Viral medicine.disease Transplantation Cell Transformation Neoplastic medicine.anatomical_structure Cell culture Culture Media Conditioned Cancer research Stem cell |
| Zdroj: | Oncogene. 19:2780-2785 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/sj.onc.1203589 |
| Popis: | Angiogenesis was identified as an early consequence of myc gene overexpression in two models of retroviral lymphomagenesis. Avian leukosis virus (ALV) induces bursal lymphoma in chickens after proviral c-myc gene integration, while the HB-1 retrovirus carries a v-myc oncogene and also induces metastatic lymphoma. Immunohistochemical studies of the effects of increased c-myc or v-myc overexpression revealed early angiogenesis within myc-transformed bursal follicles, which persisted in lymphomas and metastases. Abnormal vessel growth was consistently detected within 13 days after transplantation of a few myc-overexpressing progenitors into ablated bursal follicles, suggesting that these angiogenic changes may support the initial expansion of tumor precursors, as well as later stage lymphomagenesis. Conditioned media from myc-overexpressing B cell lines promoted proliferation of vascular endothelium in vitro, while media from B cells expressing low myc levels showed little effect. Moreover, ectopic myc overexpression in the low myc B cell lines increased production of the endothelial growth activity, indicating that myc induces secretion of angiogenic factors from B cells. These findings demonstrate that myc overexpression in lymphocytes generates an angiogenic phenotype in vitro as well as in vivo. Oncogene (2000). |
| Databáze: | OpenAIRE |
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