A randomized controlled trial of relapse prevention therapy for first-episode psychosis patients
| Autor: | Patrick D. McGorry, Darryl Wade, Kingsley Crisp, Daniela Spiliotacopoulos, Sue M. Cotton, Tracey Pearce, John Gleeson, David J. Castle, Donna Gee, Mario Alvarez-Jimenez, Belinda Newman |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Psychosis Adolescent Substance-Related Disorders medicine.medical_treatment Relapse prevention Severity of Illness Index law.invention Young Adult Randomized controlled trial law Severity of illness Brief Psychiatric Rating Scale Secondary Prevention medicine Humans Psychiatry First episode Cognitive Behavioral Therapy business.industry medicine.disease Diagnostic and Statistical Manual of Mental Disorders Cognitive behavioral therapy Psychiatry and Mental health Psychotic Disorders Quality of Life Number needed to treat Female business Antipsychotic Agents |
| Popis: | Patients with first-episode psychosis are responsive to acute-phase treatments, but relapse rates are high. This study aimed to evaluate the effectiveness of a psychosocial treatment designed to prevent the second episode of psychosis compared with standardized early psychosis care.In a randomized controlled trial, conducted at the Early Psychosis Prevention and Intervention Centre and Barwon Health, Australia, a multimodal individual and family cognitive-behavioral therapy for relapse prevention was compared with standardized case management within a specialist early psychosis service. Patients aged 15 to 25 years with a first episode of a DSM-IV psychotic disorder were recruited between November 2003 and May 2005. The main outcome measures were the number of relapses and time to first relapse.Forty-one first-episode psychosis patients were randomly assigned to the relapse prevention therapy (RPT) and 40 to standardized case management. At the 7-month follow up, the relapse rate was significantly lower in the therapy condition compared to treatment as usual (p = .042) and time to relapse was significantly longer for the RPT condition (p = .03). The number needed to treat was 6 over 7 months.Interim findings suggest that RPT provided within a specialist early psychosis program was effective in reducing relapse in early psychosis when compared with standardized early psychosis case management.www.anzctr.org.au Identifier: ACTRN12605000514606. |
| Databáze: | OpenAIRE |
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