PAI-1 4G/5G insertion/deletion promoter polymorphism and microvascular complications in type 2 diabetes mellitus
| Autor: | Markus Exner, Oswald Wagner, Christine Mannhalter, Heidemarie Abrahamian, Marianne Raith, Karl Irsigler, Rudolf Prager, Harald Mauler, Rodrig Marculescu, Lukas Endler, Georg Endler, Marion Funk, Angelika Grimm |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Heterozygote Population DNA Mutational Analysis Type 2 diabetes Risk Assessment Diabetic nephropathy Risk Factors Internal medicine Genotype Plasminogen Activator Inhibitor 1 medicine Biomarkers Tumor Humans Genetic Predisposition to Disease Genetic Testing education Promoter Regions Genetic Aged education.field_of_study Diabetic Retinopathy Polymorphism Genetic business.industry Type 2 Diabetes Mellitus General Medicine Diabetic retinopathy Middle Aged medicine.disease Endocrinology Diabetes Mellitus Type 2 Austria Albuminuria DNA Transposable Elements Female Aryl Hydrocarbon Hydroxylases medicine.symptom business Gene Deletion Retinopathy |
| Zdroj: | Wiener klinische Wochenschrift. 117(19-20) |
| ISSN: | 0043-5325 |
| Popis: | BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) plays an important role in the regulation of fibrinolysis and extracellular matrix turnover. PAI-1 4G/5G insertion/deletion polymorphism in the PAI-1 promoter region has been shown to modulate PAI-1 plasma levels. We investigated the relationship between this polymorphism and the prevalence of diabetic nephropathy and retinopathy in patients with type 2 diabetes in the Austrian population. PATIENTS AND METHODS: 147 consecutive patients with type 2 diabetes mellitus (96 men, 51 women; median age, 65 years; IQR, 59–71) were analyzed for the PAI-1 4G/5G genotype. RESULTS: The genotype distribution in the individuals tested was as follows: 17% (n = 25) 5G/5G, 54% (n = 80) 4G/5G, and 29% (n = 42) 4G/4G. Patients homozygous for allele 4G had a significantly higher risk of diabetic proliferative retinopathy than patients without signs of diabetic retinopathy or nonproliferative retinopathy (OR, 7.3; 95% CI, 1.4–38.8; P = 0.02). No significant associations were observed between the PAI-1 genotype and the presence of albuminuria. CONCLUSION: According to our results, diabetic proliferative retinopathy might be associated with the prevalence of PAI-1 genotype 4G/4G. |
| Databáze: | OpenAIRE |
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