Calcification of the splenic, iliac, and breast arteries and risk of all-cause and cardiovascular mortality
| Autor: | Michael H. Criqui, Wei Ning Sun, C. Michael Wright, Eva J.E. Hendriks, Matthew A. Allison, Joachim H. Ix, Joline W.J. Beulens, Pim A. de Jong, Yvonne T. van der Schouw |
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| Přispěvatelé: | Epidemiology and Data Science, APH - Health Behaviors & Chronic Diseases, ACS - Heart failure & arrhythmias |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Aging Time Factors åMortality 030204 cardiovascular system & hematology Splenic artery Cardiorespiratory Medicine and Haematology Cardiovascular Severity of Illness Index California 0302 clinical medicine Risk Factors Cause of Death Prevalence Whole Body Imaging Breast Tomography Cardiovascular risk factors Cause of death Cancer Vascular calcification Medial arterial calcification screening and diagnosis Arteries Middle Aged Prognosis X-Ray Computed Arterial calcification Detection Heart Disease Cardiovascular Diseases Predictive value of tests Cardiology Female Radiology Cardiology and Cardiovascular Medicine medicine.medical_specialty Clinical Sciences Iliac Artery Article 03 medical and health sciences Peripheral Arterial Disease Predictive Value of Tests Internal medicine medicine.artery Severity of illness Breast Cancer medicine Journal Article Humans cardiovascular diseases Mortality Vascular Calcification Heart Disease - Coronary Heart Disease Proportional Hazards Models Aged business.industry Prevention Case-control study medicine.disease 4.1 Discovery and preclinical testing of markers and technologies Logistic Models Good Health and Well Being Cardiovascular System & Hematology Case-Control Studies Multivariate Analysis business Tomography X-Ray Computed Splenic Artery 030217 neurology & neurosurgery Calcification |
| Zdroj: | Atherosclerosis, 259, 120. Elsevier Hendriks, E J E, Beulens, J W J, de Jong, P A, van der Schouw, Y T, Sun, W N, Wright, C M, Criqui, M H, Allison, M A & Ix, J H 2017, ' Calcification of the splenic, iliac, and breast arteries and risk of all-cause and cardiovascular mortality ', Atherosclerosis, vol. 259, pp. 120-127 . https://doi.org/10.1016/j.atherosclerosis.2017.01.029 Atherosclerosis, 259, 120-127. Elsevier Ireland Ltd |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2017.01.029 |
| Popis: | Background and aimsCVD risks associated with coronary artery calcification (CAC) and aortic calcification (AC) are well known, but less is known about other calcified arteries. We aimed to assess the associations of arterial calcification in the breast, splenic, and internal and external iliac arteries with CVD risk factors and mortality.MethodsWe conducted a case-cohort study nested in a cohort of 5196 individuals who self-referred or were referred by a health care provider for whole body computed tomography (CT), including a random subcohort (n=395) and total and CVD mortality cases (n=298 and n=90), who died during a median follow-up of 9.4 years. Arterial calcification in the breast, splenic, and internal and external iliac arteries on CT was scored using a simple visual score. AC and CAC were previously measured using the Agatston technique. Logistic regression models were made to study associations of CVD risk factors with calcification in the different vascular beds. Prentice-weighted Cox proportional hazards models adjusted for CVD risk factors, and calcification in other vascular beds, were used to study associations with mortality.ResultsIn the subcohort, the mean age was 56.6 years (SD 11.1) and 41.3% were female. The prevalence of calcification on CT, was 11.6% in the splenic, 47.9% in the internal iliac and 9.5% in the external iliac arteries, while 3.7% of women had breast artery calcification (BAC). Calcification in the splenic and iliac arteries was associated with calcification in the abdominal aorta but differentially associated with other CVD risk factors in logistic regression models. The prevalence of BAC was too low to fit these multivariable models. Calcification of the external iliac arteries was significantly associated with both all-cause and CVD mortality, but no longer significant when adjusted for CVD risk factors. Breast artery calcification was associated with both all-cause and CVD mortality independent of CVD risk factors and AAC and CAC (all-cause HR 5.67 [95% CI 1.50-21.41]).ConclusionsRisk factors associated with calcification, and the association of calcification with risk of mortality differ across vascular beds, possibly reflecting different pathophysiology. |
| Databáze: | OpenAIRE |
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