| Autor: |
Daria Onichtchouk, Carsten O. Daub, Damir Baranasic, Ada Jimenez Gonzalez, Freek van Eeden, Nan Li, Sepand Rastegar, Marcus H. Stoiber, Abdul Kadir Mukarram, Vanessa Chong, Tobias Zehnder, Dennis Wang, Irene Stevens, Joseph W. Wragg, Csilla Várnai, Wolfgang Kopp, Ferenc Müller, Juan M. Vaquerizas, José Luis Gómez-Skarmeta, Sinnakaruppan Mathavan, Scott A. Lacadie, Uwe Ohler, Maciej Lapinski, Hyejeong R. Kim, Shawn M. Burgess, Benjamín Hernández Rodríguez, Fiona C. Wardle, Tatjana Sauka-Spengler, Matthias Hörtenhuber, Zelin Chen, Alison C. McGarvey, Anne E. Eagle, Monte Westerfield, Ozren Bogdanovic, Samuel E. Ross, Noelia Díaz, Cecilia Lanny Winata, Martin Vingron, Piotr J. Balwierz, Piero Carninci, Chirag Nepal, Ryan Martin, Bernard Peers, Ben Brown, Boris Lenhard, Emily V. Chambers, Rafael D. Acemel, Silvia Naranjo, Yavor Hadzhiev, Pelumi Obasaju, Michaël Dong, Fabio M. D’Orazio |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
bioRxiv |
| Popis: |
Zebrafish, a popular model for embryonic development and for modelling human diseases, has so far lacked a systematic functional annotation programme akin to those in other animal models. To address this, we formed the international DANIO-CODE consortium and created the first central repository to store and process zebrafish developmental functional genomic data. Our Data Coordination Center (https://danio-code.zfin.org) combines a total of 1,802 sets of unpublished and reanalysed published genomics data, which we used to improve existing annotations and show its utility in experimental design. We identified over 140,000 cis-regulatory elements in development, including novel classes with distinct features dependent on their activity in time and space. We delineated the distinction between regulatory elements active during zygotic genome activation and those active during organogenesis, identifying new aspects of how they relate to each other. Finally, we matched regulatory elements and epigenomic landscapes between zebrafish and mouse and predict functional relationships between them beyond sequence similarity, extending the utility of zebrafish developmental genomics to mammals. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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