Genetic polymorphism (Arg353→Gln) in coagulation factor VII gene and factor VII levels (coagulant activity, antigen and binding ability to tissue factor) in 101 healthy Japanese
| Autor: | O Takamiya |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Clinical Biochemistry Biology Polymerase Chain Reaction Thromboplastin chemistry.chemical_compound Tissue factor Asian People Japan Antigen Internal medicine medicine Humans Antigens Allele Gene Triglycerides Polymorphism Genetic Factor VII Triglyceride DNA General Medicine Middle Aged Binding ability Endocrinology chemistry Immunology Female |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 55:211-215 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.3109/00365519509089615 |
| Popis: | We studied the frequency of the Msp I genotype (Gln353) for factor VII in 101 young healthy Japanese individuals, and the levels of factor VII-related procoagulant activity (FVII:c), antigen (FVII:ag) and binding ability to tissue factor (FVII-TF binding). The frequency of the allele coding for the factor VII Gln353 was 0.05 among this group. Individuals with genotype M1M1 had an FVII:c of 103.52 +/- 17.85% (mean +/- SD), FVII:ag of 102.50 +/- 18.42% (mean +/- SD) and FVII-TF binding of 101.03 +/- 22.22% (mean +/- SD). Triglyceride levels of subjects with the M1M1 genotype were 84.34 +/- 44.97 mg dl-1 (mean +/- SD). FVII:c (50%), FVII:ag (45%) and FVII-TF binding (36%) from an individual with the M2M2 type was the lowest, with a triglyceride value of 39 mg dl-1. On the other hand, individuals with the genotype M1M2 had an FVII:c of 75.57 +/- 9.61% (mean +/- SD), FVII:ag of 72.43 +/- 8.54% (mean +/- SD) and FVII-TF binding of 68.14 +/- 14.91% (mean +/- SD). FVII:c, FVII:ag and FVII-TF binding in individuals with the M1M2 and M2M2 genotypes were significantly lower than those in individuals with the M1M1 genotype. |
| Databáze: | OpenAIRE |
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