The role of IP prostanoid receptors in inflammatory pain
| Autor: | Richard M. Eglen, J A M Smith, John C. Hunter, Keith R. Bley |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Receptors Prostaglandin Pain Prostaglandin Inflammation Pharmacology Toxicology chemistry.chemical_compound Internal medicine medicine Animals Humans Receptor Chemistry Prostanoid Epoprostenol Endocrinology medicine.anatomical_structure Nociception Hyperalgesia lipids (amino acids peptides and proteins) medicine.symptom Endogenous agonist Sensory nerve |
| Zdroj: | Trends in Pharmacological Sciences. 19:141-147 |
| ISSN: | 0165-6147 |
| DOI: | 10.1016/s0165-6147(98)01185-7 |
| Popis: | Prostanoid receptor-mediated sensitization of sensory nerve fibres is a key contributor to the generation of hyperalgesia. It is generally thought that prostaglandin (PG) E2 is the principal pro-inflammatory prostanoid. Consequently, prostanoid EP receptors on sensory neurones have been identified as potential therapeutic targets. However, IP prostanoid receptors are also present on sensory neurones, and recent data from transgenic mice lacking the IP receptor demonstrate its importance in the induction of oedema and pain behaviour. PGI2, the primary endogenous agonist for the IP receptor, is rapidly produced following tissue injury or inflammation; thus, it may be of equal, or greater, importance than PGE2 during episodes of inflammatory pain. In this review, Keith Bley, John Hunter, Richard Eglen and Jacqueline Smith compare the roles of EP and IP receptors in nociception and suggest that the IP receptor constitutes a novel target for anti-nociceptive agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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