Pentagone: patrolling BMP morphogen signaling
| Autor: | Markus Affolter, Robin Vuilleumier, George Pyrowolakis |
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| Rok vydání: | 2011 |
| Předmět: |
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Physiological Extracellular Matrix Proteins animal structures Ecology Novel protein Morphogen activity Regulator Animal development Biology Bone morphogenetic protein Cell biology body regions Drosophila melanogaster Insect Science embryonic structures Bone Morphogenetic Proteins Animals Drosophila Proteins hormones hormone substitutes and hormone antagonists Morphogen |
| Zdroj: | Fly. 5(3) |
| ISSN: | 1933-6942 |
| Popis: | Orchestration of spatial organization by signaling gradients - morphogen gradients - is a fundamental principle in animal development. Despite their importance in tissue patterning and growth, the exact mechanisms underlying the establishment and maintenance of morphogen gradients are poorly understood. Our recent work on BMP (bone morphogenetic protein) morphogen signaling during wing development identified a novel protein, Pentagone (Pent), as a critical regulator of morphogen activity. In the following, we discuss the properties of Pent and its role as a feed-back loop in morphogen gradient formation. |
| Databáze: | OpenAIRE |
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