Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer
| Autor: | Z. Serefoglou, Stavros Vassiliou, Ingo N.G. Springer, Antonis Vylliotis, Peter Kessler, Jörg Wiltfang, Christos Yapijakis, Eleftherios Vairaktaris, Spyridoula Derka, Friedrich-Wilhelm Neukam, Emeka Nkenke |
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| Rok vydání: | 2006 |
| Předmět: |
Genotype
Integrin alpha2 In Vitro Techniques medicine.disease_cause Polymerase Chain Reaction law.invention Metastasis law Gene expression Humans Medicine Genetic Predisposition to Disease Allele Alleles Polymerase chain reaction Retrospective Studies Regulation of gene expression Mouth neoplasm Polymorphism Genetic business.industry DNA Neoplasm General Medicine medicine.disease Gene Expression Regulation Neoplastic Oncology Mutation Immunology Mouth Neoplasms Surgery business Carcinogenesis |
| Zdroj: | European Journal of Surgical Oncology (EJSO). 32:455-457 |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2005.12.005 |
| Popis: | In light to association of increased platelet glycoprotein Ia (GPIa) expression with tumor invasion and metastasis in several types of cancer, we investigated the possible contribution of a common polymorphism (C807/T807), affecting the GPIa gene expression, in the development of oral cancer.DNA samples of 110 patients with oral cancer and 114 healthy controls were examined by allele-specific polymerase chain reaction followed by electrophoretic analysis.The mutant T807 allele homozygotes were significantly increased in the group of patients compared to the control group (P0.001). Furthermore, significantly increased frequency of mutant alleles compared to controls was observed in the subgroup of patients with a positive history for cancer (P0.01).The obtained results indicate that the C807/T807 polymorphism is indeed a genetic predisposing factor which contributes to increased risk for oral cancer. |
| Databáze: | OpenAIRE |
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