Wrapping up histone regulation
| Autor: | Esther Schnapp |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Regulation of gene expression
Histone-modifying enzymes biology DNA repair Computational biology Bioinformatics Biochemistry Chromatin remodeling Chromatin Histone Code Histones Histone Editorial Gene Expression Regulation Genetics biology.protein Histone code Animals Humans Epigenetics Molecular Biology |
| Zdroj: | EMBO reports. 16(11) |
| ISSN: | 1469-3178 |
| Popis: | “Histones and Chromatin”, a new review series in EMBO Reports and The EMBO Journal on histones, the chief protein components of chromatin, provides a state‐of‐the‐art focus on molecular mechanistic understanding of the regulation of chromatin. The review series is centered on the histone code hypothesis, rather than the epigenetic code—i.e. excluding DNA modifications. Since the histone code concept was first proposed, the field has assembled a large catalogue of histone modifications and a broad range of regulatory outputs. The series focuses on histones, including the often neglected H1 linker histones, on histone variants and chaperones, and on the structural basis of their interactions. It covers writers, readers and erasers of histone modifications and their role in nuclear organization. Throughout, the aim is to integrate the functional roles of all these components in chromatin compaction and regulation, transcription and DNA repair. While there is no dedicated analysis of the role of histone modification in disease, the reviews are relevant in this context, given the profound … |
| Databáze: | OpenAIRE |
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