High-grade gliomas in adolescents and young adults highlight histomolecular differences from their adult and pediatric counterparts
| Autor: | Arnault Tauziède-Espariat, Karima Mokhtari, Steven Knafo, Emmanuel Mandonnet, Pascale Varlet, Fabrice Chrétien, Marc Polivka, Clovis Adam, Johan Pallud, Marie-Anne Debily, Albane Gareton, Dominique Figarella-Branger, Thierry Faillot, Raphaël Saffroy, Marc Sanson, Alexandre Roux, Stéphanie Puget, Mathilde Desplanques, Frédéric Dhermain, Jacques Grill, François Doz, Franck Bourdeaut, Aurélie Dauta, Myriam Edjlali-Goujon, Nathalie Boddaert, Mélanie Pagès, Dominique Cazals-Hatem, Georges Dorfmüller |
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| Přispěvatelé: | Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Anatomie Pathologique-Neuropathologique [AP-HM Hôpital La Timone], Hôpital de la Timone [CHU - APHM] (TIMONE) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty [SDV]Life Sciences [q-bio] World health whole exome sequencing 03 medical and health sciences 0302 clinical medicine Internal medicine Glioma glioma medicine Young adult 10. No inequality Exome sequencing business.industry glioblastoma Retrospective cohort study medicine.disease humanities 3. Good health Isocitrate dehydrogenase 030220 oncology & carcinogenesis Immunohistochemistry DNA-methylation analysis Neurology (clinical) Oligodendroglioma business 030217 neurology & neurosurgery integrated diagnosis |
| Zdroj: | Neuro-Oncology Neuro-Oncology, 2020, 22 (8), pp.1190-1202. ⟨10.1093/neuonc/noaa024⟩ Neuro-Oncology, Oxford University Press (OUP), 2020, 22 (8), pp.1190-1202. ⟨10.1093/neuonc/noaa024⟩ |
| ISSN: | 1522-8517 1523-5866 |
| DOI: | 10.1093/neuonc/noaa024⟩ |
| Popis: | Background Considering that pediatric high-grade gliomas (HGGs) are biologically distinct from their adult counterparts, the objective of this study was to define the landscape of HGGs in adolescents and young adults (AYAs). Methods We performed a multicentric retrospective study of 112 AYAs from adult and pediatric Ile-de-France neurosurgical units, treated between 1998 and 2013 to analyze their clinicoradiological and histomolecular profiles. The inclusion criteria were age between 15 and 25 years, histopathological HGG diagnosis, available clinical data, and preoperative and follow-up MRI. MRI and tumoral samples were centrally reviewed. Immunohistochemistry and complementary molecular techniques such as targeted/next-generation sequencing, whole exome sequencing, and DNA-methylation analyses were performed to achieve an integrated diagnosis according to the 2016 World Health Organization (WHO) classification. Results Based on 80 documented AYA patients, HGGs constitute heterogeneous clinicopathological and molecular groups, with a predominant representation of pediatric subtypes (histone H3-mutants, 40%) but also adult subtypes (isocitrate dehydrogenase [IDH] mutants, 28%) characterized by the rarity of oligodendrogliomas, IDH mutants, and 1p/19q codeletion and the relative high frequency of “rare adult IDH mutations” (20%). H3G34-mutants (14%) represent the most specific subgroup in AYAs. In the H3K27-mutant subgroup, non-brainstem diffuse midline gliomas are more frequent (66.7%) than diffuse intrinsic pontine gliomas (23.8%), contrary to what is observed in children. We found that WHO grade has no prognostic value, but molecular subgrouping has major prognostic importance. Conclusions HGGs in AYAs could benefit from a specific classification, driven by molecular subtyping rather than age group. Collaborative efforts are needed from pediatric and adult neuro-oncology teams to improve the management of HGGs in AYAs. |
| Databáze: | OpenAIRE |
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