Olive oil decreases liver damage in rats caused by carbon tetrachloride (CCl4)
| Autor: | F. Timár, B. Hargitai, Béla Szende |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Time Factors Connective tissue CCL4 Toxicology Liver Cirrhosis Experimental digestive system Pathology and Forensic Medicine chemistry.chemical_compound Animal science Fish Oils Dietary Fats Unsaturated parasitic diseases medicine Animals Plant Oils Sunflower Oil Drug Interactions Olive Oil Chemistry Carbon Tetrachloride Poisoning Cell Biology General Medicine Fish oil Sunflower digestive system diseases Rats Inbred F344 Staining Rats Solvent medicine.anatomical_structure Biochemistry Liver Connective Tissue Carbon tetrachloride Helianthus Collagen Corn Oil Olive oil |
| Zdroj: | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 46(4-5) |
| ISSN: | 0940-2993 |
| Popis: | Summary Oral carbon tetrachloride (CCl4) poisoning of the liver of male F-344 rats was modified by dissolving CCl4 in various oils (sunflower, corn, fish and olive). After 8 weeks of CCl4 treatment (3 × 0.2 ml/kg body weight every other day, dissolved in aliquots of 0.5 ml of each types of oil) the rats were sacrificed and the ratio of connective tissue in the liver was determined by morphometry after picrosirius staining. The percentage of collagen fibres increased in all CCl4-treated groups compared to the controls. This increase was almost the same (6–8 %) in the case of CCl4 dissolved in sunflower, corn or fish oil, but when olive oil was applied as a solvent, the collagen ratio was only 2–4 percent. On the bases of this finding olive oil is considered as less harmful to the liver in acute CCl4 poisoning than other oils. |
| Databáze: | OpenAIRE |
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