Expression of type III interferons (IFNλs) and their receptor in Sjögren's syndrome

Autor:	Evangelos Andreakos, Maria Ioanna Saridaki, Efstathia K. Kapsogeorgou, Athanasios G. Tzioufas, O.D. Konsta, Ioannis Giotakis, Eirini Apostolou
Rok vydání:	2016
Předmět:	Adult Male 0301 basic medicine Exocrine gland Adolescent Biopsy Immunology Gene Expression Inflammation Stimulation Biology medicine.disease_cause Peripheral blood mononuclear cell Salivary Glands Autoimmunity Interferon-gamma Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Immunology and Allergy RNA Messenger Receptor Aged Receptors Interferon 030203 arthritis & rheumatology Salivary gland Original Articles Middle Aged Immunohistochemistry Toll-Like Receptor 3 Sjogren's Syndrome 030104 developmental biology medicine.anatomical_structure TLR3 Female medicine.symptom Biomarkers
Zdroj:	Clinical and Experimental Immunology. 186:304-312
ISSN:	1365-2249 0009-9104
DOI:	10.1111/cei.12865
Popis:	Summary Type III interferons (IFNs) or IFN-λs (IFN-λ1/IL29, IFN-λ2/interleukin (IL)−28A and IFN-λ3/IL-28B) consist of a recently identified group of IFNs, implicated initially in several human diseases, including cancer and autoimmunity. In this study, we sought to investigate the expression of type III IFNs and their common receptor IFN-λR1/IL-28Ra in Sjögren's syndrome (SS). Type III IFN expression was examined in minor salivary gland tissues (MSG), peripheral blood mononuclear cells (PBMCs), sera and resting or Toll-like receptor (TLR)-stimulated salivary gland epithelial cells (SGEC) from SS patients and sicca-complaining controls. All type III IFN family members were detected in ductal and acinar epithelia of MSGs from both SS patients and sicca controls. IFN-λ2/IL-28A and IFN-λ3/IL-28B were also expressed in infiltrating mononuclear cells. In SS patients with intermediate MSG lesions, the epithelial expression of IFN-λ2/IL-28A was more intense compared to sicca controls (P
Databáze:	OpenAIRE
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