Effect of Recombinant Human Growth Hormone on Regional Tissue Distribution in Growth Hormone-Deficient Males
| Autor: | J. S. Davies, William D. Evans, W. Bell, M. F. Scanlon |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Biology Growth hormone Placebo General Biochemistry Genetics and Molecular Biology law.invention Absorptiometry Photon Double-Blind Method History and Philosophy of Science Bone Density law Internal medicine medicine Humans In patient Tissue distribution Bone mineral Anthropometry Human Growth Hormone General Neuroscience Human growth hormone Middle Aged Trunk Body Height Endocrinology Adipose Tissue Body Composition Recombinant DNA Body Constitution |
| Zdroj: | Annals of the New York Academy of Sciences. 904:576-583 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.2000.tb06519.x |
| Popis: | Dual-energy X-ray absorptiometry was used to analyze the regional tissue distribution of bone mineral mass (BMM), fat mass (FM), and lean tissue mass (LTM) in the arms, trunk, and legs of 23 male growth hormone-deficient (GHD) males. Patients were assigned randomly to treatment (n = 11) and control (n = 12) groups. During the first six months, the treatment group received recombinant growth hormone (rhGH) and the control group placebo. During the second six months, both groups received rhGH. Following treatment there was a trend for BMM to be lost in the arms and legs, with gains at the trunk. Fat mass was lost mainly from the trunk. Proportionally more LTM was distributed to the arms and legs than to the trunk. Treatment was more effective in the first six months than the second. The correlation between the waist-hip ratio and trunk fat was poor, suggesting that its use in patients with GHD may be misleading. |
| Databáze: | OpenAIRE |
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