The inhibitory effect of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) on estrogen-dependent mammary tumors
| Autor: | J. Prekajac, Mathias Berger, E. von Angerer, Martin R. Schneider |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Cancer Research
medicine.medical_specialty Indoles Neoplasms Hormone-Dependent medicine.drug_class Mammary gland Estrogen receptor Antineoplastic Agents Biology Cell Line Mice Internal medicine medicine Animals Cytotoxic T cell Endocrine system Mammary tumor Mammary Neoplasms Experimental Estrogens General Medicine In vitro Rats Endocrinology medicine.anatomical_structure Oncology Mechanism of action Estrogen medicine.symptom |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 110:216-220 |
| ISSN: | 1432-1335 0171-5216 |
| Popis: | The antineoplastic activity of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) was determined in several estrogen-dependent mammary tumor models. The growth of DMBA-induced rat mammary carcinomas was inhibited by doses ranging from 2 to 18 mg/kg. A dose of 6 X 12 mg/kg per week p.o. reduced the tumor area by 82% (control + 192%). D 15413 was also active against MNU-induced rat mammary tumors and transplanted MXT tumors of the mouse. In vitro, the growth of estrogen receptor positive MCF-7 breast cancer cells was inhibited by D 15413 (10(-8) - 10(-5) M). A mode of action considering endocrine and cytotoxic effects is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink