Extensive chronic GVHD is associated with donor blood CD34+ cell count after G-CSF mobilization in non-myeloablative allogeneic PBSC transplantation
| Autor: | Sandrine Katsahian, N. Piard, J. H. Bourhis, Pierre Bordigoni, J A Ribeil, M Kuentz, Françoise Norol, Mauricette Michallet, Pierre Tiberghien, Thomas Prebet, Nathalie Dhedin, J P Jouet, R. Peffault de Latour, Delphine Rea, Didier Blaise, J P Vernant, Bernard Rio, Anne Sirvent, Reza Tabrizi, Bruno Lioure |
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| Přispěvatelé: | Service de Greffe de Moelle - Unité AJA, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Transplantation et de Thérapie Cellulaire, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Service de greffe de moelle osseuse [Saint-Louis], Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Biostatistiques, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service d'hématologie clinique, Etablissement Français du Sang Pays de la Loire, EFS, Unité de Thérapie Cellulaire et de Clinique Transfusionnelle, CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service des Maladies du Sang, Hôpital Claude Huriez [Lille], CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Biothérapie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre de référence des syndromes drépanocytaires majeurs-CHU Necker - Enfants Malades [AP-HP], Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux]-CHU Bordeaux [Bordeaux], Service d'Hématologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel Dieu, Service d'onco-hématologie, CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Unité de Thérapie Cellulaire, Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Hématologie, Département de médecine oncologique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Service d'Hématologie et d'Oncologie Médicale, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Unité de Transplantation Médullaire, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Hôpital d'enfants, Service d'hématologie [Hôpital Edouard Herriot - HCL], Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Saas, Philippe, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty [SDV.IMM] Life Sciences [q-bio]/Immunology CD3 Cell CD34 Graft vs Host Disease Antigens CD34 Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Granulocyte Colony-Stimulating Factor Humans Transplantation Homologous Medicine Aged Retrospective Studies Peripheral Blood Stem Cell Transplantation Transplantation Mobilization biology business.industry Incidence (epidemiology) Hematology Middle Aged Hematopoietic Stem Cells Hematopoietic Stem Cell Mobilization 3. Good health Fludarabine Regimen medicine.anatomical_structure Quartile 030220 oncology & carcinogenesis Chronic Disease Immunology biology.protein [SDV.IMM]Life Sciences [q-bio]/Immunology business 030215 immunology medicine.drug |
| Zdroj: | Bone Marrow Transplantation Bone Marrow Transplantation, Nature Publishing Group, 2012, 47 (12), pp.1564-8. ⟨10.1038/bmt.2012.75⟩ Bone Marrow Transplantation, 2012, 47 (12), pp.1564-8. ⟨10.1038/bmt.2012.75⟩ |
| ISSN: | 0268-3369 |
| DOI: | 10.1038/bmt.2012.75⟩ |
| Popis: | International audience; The correlation between the incidence of GVHD and the number of infused CD34(+) cells remains controversial for PBSC transplantation after a reduced-intensity-conditioning (RIC) regimen. We evaluated 99 patients transplanted with an HLA-identical sibling after the same RIC (2-Gy-TBI/fludarabine). Donor and recipient characteristics, donor's blood G-CSF-mobilized CD34(+) cell count, and number of infused CD34(+) and CD3(+) cells were analyzed as risk factors for acute and chronic GVHD There was a trend for an increased incidence of extensive chronic GVHD in the quartile of patients receiving more than 10 × 10(6) CD34(+) cells/kg (P = 0.05). Interestingly, the number of donor's blood CD34(+) cells at day 5 of G-CSF mobilization was closely associated with the incidence of extensive chronic GVHD, that is, 48% (95% CI: 28-68) at 24-months in the quartile of patients whose donors had the highest CD34(+) cell counts versus 24.3% (95% CI: 14-34) in the other patients (P = 0.007). In multivariate analysis, the only factor correlating with extensive chronic GVHD (cGVHD) was the donor's blood CD34(+) cell count after G-CSF (HR 2.49; 95% CI: 1.16-5.35, P = 0.019). This study shows that the incidence of cGVHD is more strongly associated with the donor's ability to mobilize CD34(+) cells than with the number of infused CD34(+) cells. |
| Databáze: | OpenAIRE |
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