Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers
| Autor: | Stephen T. Chambers, Mei Zhang, Ronald Begg, Richard J. Everts, John D. Turnidge, Sharon J. Gardiner, Evan J. Begg |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) 030106 microbiology Microbial Sensitivity Tests Pharmacology urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Cefalexin Healthy volunteers polycyclic compounds medicine Humans 030212 general & internal medicine Cephalexin Total plasma Probenecid business.industry Healthy Volunteers Infectious Diseases Area Under Curve Pharmacodynamics business medicine.drug |
| Zdroj: | Journal of Infection. 83:182-189 |
| ISSN: | 0163-4453 |
| DOI: | 10.1016/j.jinf.2021.05.037 |
| Popis: | Objectives: We evaluated the effects of probenecid on the Pharmaco Kinetics (PK) and pharmacodynamics (PD) of oral cephalexin in healthy volunteers. Methods: Cephalexin 1000 mg was administered orally to 11 healthy volunteers following a standardized meal, with and without probenecid 500 mg orally, on two separate days one week apart. Total plasma concentrations of cephalexin and probenecid over a 12 h period were measured by liquid chromatography tandem mass spectrometry. Standard pharmacokinetic measures and contemporary PK/PD targets were compared. Results: Probenecid increased the mean (95% CI) cephalexin area under the concentration-time curve (AUC0-∞) 1.73-fold (1.61–1.85, p Conclusions: Probenecid prolonged and flattened the plasma concentration-time curve, enhancing the probability of attaining PK/PD targets. Co-administration of probenecid may expand the clinical benefits of oral cephalexin. |
| Databáze: | OpenAIRE |
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