Natural history of bone metastasis in colorectal cancer: final results of a large Italian bone metastases study
| Autor: | Bruno Vincenzi, Evaristo Maiello, Cristina Masini, Olga Venditti, Raffaele Addeo, Alfredo Falcone, Vincenzo Catalano, Vladimir Virzì, Cinzia Ortega, R. Giannicola, N. Calipari, Toni Ibrahim, Giuseppe Tonini, Paolo Giordani, Calogero Mazzara, Azzurra Ottone, Fausto Petrelli, Stefano Cascinu, Nicola Silvestris, Federica Bertolini, Daniele Santini, Lisa Salvatore, Sandro Barni, Tiziana Latiano, Maria Elisabetta Fratto, Marco Tampellini, Cinzia Caroti, Rossana Berardi, Massimo Aglietta, Giuseppe Badalamenti, Davide Ottaviani, Francesco Fabbri |
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| Přispěvatelé: | Santini, D, Tampellini, M, Vincenzi, B, Ibrahim, T, Ortega, C, Virzi, V, Silvestris, N, Berardi, R, Masini, C, Calipari, N, Ottaviani, D, Catalano, V, Badalamenti, G, Giannicola, R, Fabbri, F, Venditti, O, Fratto, Me, Mazzara, C, Latiano, Tp, Bertolini, F, Petrelli, F, Ottone, A, Caroti, C, Salvatore, L, Falcone, A, Giordani, P, Addeo, R, Aglietta, M, Cascinu, Stefano, Barni, S, Maiello, E, Tonini, G., Santini d, Tampellini m, Vincenzi b, Ibrahim t, Ortega c, Virzi v, Silvestris n, Berardi r, Masini c, Calipari n, Ottaviani d, Catalano v, Badalamenti g, Giannicola r, Fabbri f, Venditti o, Fratto e, Mazzara c, Latiano tp, Bertolini f, Petrelli f, Ottone a, Caroti c, Salvatore l, Falcone a, Giordani p, Addeo r, Aglietta m, Cascinu, Barni s., Maiello e, Tonini g |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Oncology
medicine.medical_specialty Bone Density Conservation Agent Settore MED/06 - Oncologia Medica Colorectal cancer Bone Neoplasms Colorectal Neoplasm Bone Neoplasm drug therapy/pathology Zoledronic Acid Internal medicine medicine Humans Imidazole Pelvis Retrospective Studies drug therapy/secondary bone metastases colorectal cancer zoledronic acid Bone Density Conservation Agents Diphosphonates business.industry Imidazoles Bone metastasis Cancer Retrospective cohort study Hematology medicine.disease Natural history Zoledronic acid medicine.anatomical_structure Diphosphonate therapeutic use Colorectal Neoplasms business Human medicine.drug |
| Zdroj: | Università di Pisa-IRIS |
| Popis: | Background Data are limited regarding bone metastases from colorectal cancer (CRC). The objective of this study was to survey the natural history of bone metastasis in CRC. Patients and methods This retrospective, multicenter, observational study of 264 patients with CRC involving bone examined cancer treatments, bone metastases characteristics, skeletal-related event (SRE) type and frequency, zoledronic acid therapy, and disease outcomes. Results Most patients with bone metastases had pathologic T3/4 disease at CRC diagnosis. The spine was the most common site involved (65%), followed by hip/pelvis (34%), long bones (26%), and other sites (17%). Median time from CRC diagnosis to bone metastases was 11.00 months; median time to first SRE thereafter was 2.00 months. Radiation and pathologic fractures affected 45% and 10% of patients, respectively; 32% of patients had no reported SREs. Patients survived for a median of 7.00 months after bone metastases diagnosis; SREs did not significantly affect survival. Subgroup analyses revealed that zoledronic acid significantly prolonged median time to first SRE (2.00 months versus 1.00 month, respectively, P = 0.009) and produced a trend toward improved overall survival versus no zoledronic acid. Conclusion This study illustrates the burden of bone metastases from CRC and supports the use of zoledronic acid in this setting. |
| Databáze: | OpenAIRE |
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