Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines
| Autor: | Carina Linder, Kjell Ohlsson, Ido Leden, Magnus Bruze, Bert Björkner, Halvor Möller, Åke Svensson, Jan Theander |
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| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Arthritis Gold allergy Dermatology Gold Sodium Thiomalate Gastroenterology Body Temperature Arthritis Rheumatoid Internal medicine lcsh:Dermatology medicine Humans Aged business.industry Gold Therapy lcsh:RL1-803 Middle Aged medicine.disease Dermatology and Venereal Diseases Serum cytokine Contact allergy Rheumatoid arthritis Antirheumatic Agents Immunology Dermatitis Allergic Contact Cytokines Tumor necrosis factor alpha Female business Research Article |
| Zdroj: | BMC Dermatology BMC Dermatology, Vol 2, Iss 1, p 2 (2002) BMC Dermatology; 2(1) (2002) |
| ISSN: | 1471-5945 |
| Popis: | Objective To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold. Methods Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM). Results Contact allergy to gold was found in 4 of 19 patients. Compared to gold-negative patients (starting dose: 10 mg GSTM), there was a larger increase in serum TNFalpha (p < 0.05), sTNF-R1 (NS), and IL-1 ra (p < 0.05) in gold-allergic patients. Conclusions Cytokines are released in blood by GSTM in RA patients with gold allergy. To minimize the risk of acute adverse reactions the starting dose of GSTM should be lowered to 5 mg. Alternatively, patients should be patch-tested before gold therapy; in test-positive cases, 5 mg is recommended as the first dose. |
| Databáze: | OpenAIRE |
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