A previously undescribed cutaneous paraneoplastic syndrome in a cat with thymoma
| Autor: | Quentin Fournier, Katarina Varjonen, Spela Bavcar, Sionagh Smith, Adrian Philbey |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Thymoma integumentary system General Veterinary business.industry Paraneoplastic Syndromes Radiography Postoperative complication Domestic Short Hair Cat Chylothorax Alopecia medicine.disease Follicular atrophy Computed tomographic Feline medicine Exfoliative dermatitis Differential diagnosis business |
| Zdroj: | Fournier, Q, Bavcar, S, Philbey, A, Smith, S & Varjonen, K 2019, ' A previously undescribed cutaneous paraneoplastic syndrome in a cat with thymoma ', Veterinary Dermatology . https://doi.org/10.1111/vde.12745 |
| DOI: | 10.1111/vde.12745 |
| Popis: | Background– Exfoliative dermatitis is a well-recognized cutaneous paraneoplastic syndrome (PNS) associated with thymoma in cats, of which the clinical and histopathological presentation has been well characterized.Objectives – To describe a novel clinical skin manifestation associated with thymoma in a cat Animal – A 14-year-old neutered female domestic short haired catMethods – Physical, abdominal ultrasonographic, thoracic radiographic, ultrasonographic and computed tomographic examinations, histopathologic assessment of the skin and mediastinal mass.Results – The cat was presented with non-inflammatory alopecia, with a dorsal multifocal distribution. Examination of the alopecic areas using a dermascope indicated an apparent lack of follicular ostia. Histopathological assessment of alopecic areas confirmed follicular and epidermal atrophy, trichilemmal keratinization and mild orthokeratotic hyperkeratosis. Diagnostic imaging revealed a mediastinal mass, which was surgically removed. Histopathological and immunohistopathological examination of the mass was consistent with a thymoma, associated with multiloculated cyst formation and multifocal cholesterol granulomas. Following surgery, hair re-growth was noted in the previously alopecic areas. The cat was euthanized 3.5 months later because of recurrent chylothorax, suspected to be a post-operative complication. The alopecic lesions had markedly improved.Conclusions and clinical importance – Thymoma-associated PNS might not always manifest as an exfoliative dermatitis, and should be considered in the differential diagnosis of multifocal non-inflammatory alopecia. |
| Databáze: | OpenAIRE |
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