Morphological MRI investigations of the hypothalamus in 232 individuals with Parkinson's disease

Autor: Hans-Peter Müller, Daniel G. Schmidt, Jan Kassubek, Albert C. Ludolph, Martin Gorges, Barbara Kuntz, Kelly Del Tredici, Luc Dupuis
Přispěvatelé: University of Ulm (UUlm), Mécanismes Centraux et Périphériques de la Neurodégénérescence, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Dieterle, Stéphane
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Pathology
Parkinson's disease
Movement disorders
[SDV]Life Sciences [q-bio]
Volumetric analysis
Disease
MESH: Magnetic Resonance Imaging
Cohort Studies
MESH: Aged
80 and over
0302 clinical medicine
hypothalamus
MESH: Cohort Studies
Aged
80 and over
MESH: Aged
MESH: Middle Aged
medicine.diagnostic_test
Parkinson Disease
Middle Aged
Magnetic Resonance Imaging
Pathophysiology
3. Good health
[SDV] Life Sciences [q-bio]
Parkinson disease
Neurology
Hypothalamus
Female
medicine.symptom
MR imaging
Adult
medicine.medical_specialty
Parkinson's disease neuropathological stages
MESH: Atrophy
03 medical and health sciences
Magnetic resonance imaging
Parkinsonian Disorders
In vivo
medicine
Humans
Parkinson-Krankheit
ddc:610
Aged
volumetry
MESH: Humans
MESH: Parkinsonian Disorders
business.industry
Kernspintomografie
MESH: Adult
medicine.disease
MESH: Hypothalamus
MESH: Male
Large cohort
030104 developmental biology
Neurology (clinical)
Atrophy
business
MESH: Female
MESH: Parkinson Disease
030217 neurology & neurosurgery
Zdroj: Movement Disorders
Movement Disorders, Wiley, 2019, 34 (10), pp.1566-1570. ⟨10.1002/mds.27814⟩
Movement Disorders, 2019, 34 (10), pp.1566-1570. ⟨10.1002/mds.27814⟩
ISSN: 1531-8257
0885-3185
DOI: 10.1002/mds.27814
Popis: International audience; Background: The pathophysiology of the hypothalamic involvement in Parkinson's disease (PD) is not well understood. The objective of this study was the quantification of hypothalamic volumes in vivo in PD.Methods: High-resolution T1 -weighted magnetic resonance imaging (MRI) data from 232 individuals with PD and 130 healthy non-PD individuals were used for quantification of the hypothalamic volumes.Results: The hypothalamus in PD was not atrophied, as indicated by volumetric analyses in the prospectively collected subcohort (30 PD, V = 921 ± 78 mm3 vs 30 non-PD, V = 917 ± 67 mm3 ; P = 0.850) and validated in a large cohort (202 PD, V = 925 ± 88 mm3 vs 100 non-PD, V = 932 ± 114 mm3 ; P = 0.602).Conclusions: Hypothalamic involvement in PD as shown by a large body of histopathological evidence does not appear to be detectable by MRI-based volumetric quantification. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Databáze: OpenAIRE
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