Percutaneous Toxicity and Decontamination of Soman, Vx, and Paraoxon in Rats Using Detergents
| Autor: | Jan Misik, Růžena Pavlíková, Kamil Kuca |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Detergents Soman Pharmacology Administration Cutaneous Protective Agents Toxicology Median lethal dose Paraoxon Lethal Dose 50 chemistry.chemical_compound In vivo Mass decontamination medicine Animals Chemical Warfare Agents Pesticides Rats Wistar Decontamination Nerve agent Dose-Response Relationship Drug Public Health Environmental and Occupational Health Organothiophosphorus Compounds Human decontamination Rats Survival Rate chemistry Toxicity medicine.drug |
| Zdroj: | Archives of Industrial Hygiene and Toxicology. 64:211-217 |
| ISSN: | 0004-1254 |
| DOI: | 10.2478/10004-1254-64-2013-2290 |
| Popis: | Highly toxic organophosphorus compounds (OPs) were originally developed for warfare or as agricultural pesticides. Today, OPs represent a serious threat to military personnel and civilians. This study investigates the in vivo decontamination of male Wistar rats percutaneously exposed to paraoxon and two potent nerve agents - soman (GD) and VX. Four commercial detergents were tested as decontaminants - NeodekontTM, ArgosTM, DermogelTM, and FloraFreeTM. Decontamination performed 2 min after exposure resulted in a higher survival rate in comparison with non-decontaminated controls. The decontamination effectiveness was expressed as protective ratio (PR, median lethal dose of agent in decontaminated animals divided by the median lethal dose of agent in untreated animals). The highest decontamination effectiveness was consistently achieved with ArgosTM (PR=2.3 to 64.8), followed by DermogelTM (PR=2.4 to 46.1). NeodekontTM and FloraFreeTM provided the lowest decontamination effectiveness, equivalent to distilled water (PR=1.0 to 43.2). |
| Databáze: | OpenAIRE |
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