FGF10 is a mesenchymally derived stimulator for epidermal development in the chick embryonic skin

Autor: Tsutomu Nohno, Hideyo Ohuchi, Hidefumi Yoshioka, Sumihare Noji, Yasuko Yoshimoto, Hirotaka Tao
Rok vydání: 2002
Předmět:
medicine.medical_specialty
Embryology
Bone Morphogenetic Protein 2
Chick Embryo
Bone morphogenetic protein
Bone morphogenetic protein 2
Models
Biological
Mesoderm
Transforming Growth Factor beta
Internal medicine
Proliferating Cell Nuclear Antigen
medicine
Animals
Hedgehog Proteins
Receptor
Fibroblast Growth Factor
Type 2
In Situ Hybridization
beta Catenin
Skin
Zinc finger
FGF10
integumentary system
biology
Mesenchymal stem cell
Gene Expression Regulation
Developmental
Membrane Proteins
Receptor Protein-Tyrosine Kinases
Feathers
Phosphoproteins
Embryonic stem cell
Receptors
Fibroblast Growth Factor
Proliferating cell nuclear antigen
Cell biology
DNA-Binding Proteins
Fibroblast Growth Factors
stomatognathic diseases
Cytoskeletal Proteins
Endocrinology
Bone Morphogenetic Proteins
biology.protein
Trans-Activators
Snail Family Transcription Factors
Signal transduction
Fibroblast Growth Factor 10
Signal Transduction
Developmental Biology
Zdroj: Mechanisms of Development. 116(1-2):39-49
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(02)00131-4
Popis: The development of avian cutaneous appendages, feathers and scales, is known to arise from the epithelial–mesenchymal interaction. Here we show that FGF10 is associated with this developmental process as an early signal from mesenchymal cells underlying nascent cutaneous placodes. Expression of Fgf10 was detected in the mesenchymal cells underneath the developing placodes. Forced expression of Fgf10 in the femoral skin suppressed expression of Shh and a zinc finger gene snail-related (cSnR), while induced expression of Bmp2 in the interbud region, resulting in thickening of the epidermal layer. Furthermore, forced expression of Fgf10 in the foot skin caused marked ingrowings of the epidermis. The cells in the epidermal ingrowings expressed β-catenin, proliferating cell nuclear antigen, and an epidermal stem cell marker p63. These results support the idea that FGF10 is a mesenchymally derived stimulator of epidermal development through crosstalk with bone morphogenetic protein (BMP), β-catenin, and other signaling pathways.
Databáze: OpenAIRE
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