Phase II trial of methyl-GAG (NSC-32946) in squamous cell and adenocarcinoma of the lung
| Autor: | Laurence H. Baker, Talley Rw, Glenn Cummings, Michael K. Samson |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Oncology myalgia Cancer Research medicine.medical_specialty Lung Neoplasms Mitoguazone Cell Adenocarcinoma Guanidines Drug Administration Schedule Internal medicine medicine Adenocarcinoma of the lung Mucositis Humans Infusions Parenteral Myopathy Antitumor activity business.industry Middle Aged medicine.disease medicine.anatomical_structure Carcinoma Squamous Cell Cancer research Drug Evaluation Female medicine.symptom Vasculitis business |
| Zdroj: | AMERICAN JOURNAL OF CLINICAL ONCOLOGY. 5:631-634 |
| ISSN: | 0277-3732 |
| DOI: | 10.1097/00000421-198212000-00010 |
| Popis: | Thirty-four assessable patients with advanced squamous cell and adenocarcinoma of the lung were treated with weekly MGBG in a phase II trial. Only one partial response, in adenocarcinoma, was observed. Myelosuppression was mild to moderate. Major toxicities consisted of myalgia, myopathy, mucositis, gastrointestinal and pronounced vasculitis in one patient. It would appear that MGBG does not have sufficient antitumor activity to warrant further investigation in advanced squamous cell and adenocarcinoma of the lung. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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