Suppression of mitogen-induced IL-2Rα expression in PBL by serum from microfilaraemic rats chronically infected with Brugia pahangi
| Autor: | Y. Eishi, Setsuko Tsukidate, K. Yamamoto, M. Satoh, Koichiro Fujita, N. Tamura |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Interleukin 2 Brugia pahangi Lymphocyte Alpha (ethology) chemical and pharmacologic phenomena Parasitemia Flow cytometry Immune system Leukocytes medicine Animals Microfilariae Cells Cultured Phytohaemagglutinin biology medicine.diagnostic_test Immune Sera Receptors Interleukin-2 biology.organism_classification medicine.disease Filariasis Rats Infectious Diseases medicine.anatomical_structure Rats Inbred Lew Immunology biology.protein Animal Science and Zoology Parasitology medicine.drug |
| Zdroj: | Parasitology. 114:65-69 |
| ISSN: | 1469-8161 0031-1820 |
| Popis: | To study immunological responses in filarial infections, interleukin-2 receptor α (IL-2Rα) expression in the peripheral blood lymphocytes (PBL) of Lewis rats infected with Brugia pahangi was observed by flow cytometry. During infection, no increase in IL-2Rα was observed in either microfilaraemic or amicrofilaraemic rats. The PBL of rats were stimulated with phytohaemagglutinin (PHA) and the frequency of IL-2Rα-positivity was examined. After microfilariae appeared, the increase in the rate of IL-2Rα-positivity in microfilaraemic rats was less than in amicrofilaraemic rats. The anergy of IL-2Rα expression in microfilaraemic rats was restored when their lymphocytes were cultured with normal rat serum. IL-2Rα expression in normal uninfected rats decreased when cultured with serum from microfilaraemic rats. These results suggest that microfilariae-related factors in rat serum suppress PHA-induced IL-2Rα expression in PBL and thus inhibit cell proliferation and host immunity. |
| Databáze: | OpenAIRE |
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