Fabrication and multiscale characterization of 3D silver containing bioactive glass-ceramic scaffolds
| Autor: | Natalia Pajares-Chamorro, Martin A. Crimp, Anthony W. Wren, Adam C. Marsh, Neal D. Hammer, Xanthippi Chatzistavrou, Nathan P. Mellott |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Silver Scanning electron microscope Simulated body fluid 0206 medical engineering Biomedical Engineering Energy-dispersive X-ray spectroscopy 3D glass-ceramic scaffolds Nano and macro structural properties 02 engineering and technology Bioactivity Article Antibacterial properties law.invention Biomaterials Crystallinity X-ray photoelectron spectroscopy law lcsh:TA401-492 Ceramic Fourier transform infrared spectroscopy lcsh:QH301-705.5 021001 nanoscience & nanotechnology 020601 biomedical engineering Chemical engineering lcsh:Biology (General) Bioactive glass visual_art visual_art.visual_art_medium lcsh:Materials of engineering and construction. Mechanics of materials 0210 nano-technology Biotechnology |
| Zdroj: | Bioactive Materials Bioactive Materials, Vol 4, Iss, Pp 215-223 (2019) |
| ISSN: | 2452-199X |
| Popis: | In this work, we fabricated and characterized bioactive 3D glass-ceramic scaffolds with inherent antibacterial properties. The sol-gel (solution-gelation) technique and the sacrificial template method were applied for the fabrication of 3D highly porous scaffolds in the 58.6SiO2 - 24.9CaO - 7.2P2O5 - 4.2Al2O3 – 1.5Na2O −1.5K2O – 2.1Ag2O system (Ag-BG). This system is known for its advanced bioactive and antibacterial properties. The fabrication of 3D scaffolds has potential applications that impact tissue engineering. The study of the developed scaffolds from macro-characteristics to nano-, revealed a strong correlation between the macroscale properties such as antibacterial action, bioactivity with the microstructural characteristics such as elemental analysis, crystallinity. Elemental homogeneity, morphological, and microstructural characteristics of the scaffolds were studied by scanning electron microscopy associated with energy dispersive spectroscopy (SEM-EDS), transmittance electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), and UV-visible spectroscopy methods. The compressive strength of the 3D scaffolds was measured within the range of values for glass-ceramic scaffolds with similar compositions, porosity, and pore size. The capability of the scaffolds to form an apatite-like phase was tested by immersing the scaffolds in simulated body fluid (SBF) and the antibacterial response against methicillin-resistant Staphylococcus aureus (MRSA) was studied. The formation of an apatite phase was observed after two weeks of immersion in SBF and the anti-MRSA effect occurs after both direct and indirect exposure. Graphical abstract Image 1 Highlights • Ag-BG scaffolds exhibited anti-MRSA and bioactive behavior. • Processing significantly affected microstructural characteristics of Ag-BG scaffolds. • Nano to macroscale characterization allowed tight correlation of microstructural characteristics to macroscopic properties. |
| Databáze: | OpenAIRE |
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