Altered activity in the central medial thalamus precedes changes in the neocortex during transitions into both sleep and propofol anesthesia
| Autor: | Baker, R, Gent, Thomas C, Yang, Q, Parker, S, Vyssotski, A L, Wisden, W, Brickley, S G, Franks, N P |
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| Přispěvatelé: | University of Zurich, Franks, N P, Wellcome Trust, Medical Research Council (MRC), Biotechnology and Biological Sciences Research Council (BBSRC) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Journal Club
General anesthesia Neocortex Midline thalamic nuclei Rats Sprague-Dawley Thalamus CEREBRAL-CORTEX Neural Pathways INDUCED UNCONSCIOUSNESS Animals BRAIN Propofol 11 Medical and Health Sciences sleep 10194 Institute of Neuroinformatics Science & Technology CONSCIOUSNESS Neurology & Neurosurgery Electromyography Spectrum Analysis Neurosciences 2800 General Neuroscience Electroencephalography GAMMA-OSCILLATIONS Articles LOCAL-FIELD POTENTIALS Brain Waves Electric Stimulation 17 Psychology and Cognitive Sciences Electrodes Implanted Rats GENERAL-ANESTHETICS 11404 Department of Clinical Diagnostics and Services RAT 570 Life sciences biology PEDUNCULOPONTINE NUCLEUS Neurosciences & Neurology Sleep Life Sciences & Biomedicine INTRACEREBRAL MICROINJECTION Anesthetics Intravenous |
| Zdroj: | The Journal of Neuroscience, 34 (40) |
| ISSN: | 0270-6474 1529-2401 |
| Popis: | How general anesthetics cause loss of consciousness is unknown. Some evidence points toward effects on the neocortex causing “top-down” inhibition, whereas other findings suggest that these drugs act via subcortical mechanisms, possibly selectively stimulating networks promoting natural sleep. To determine whether some neuronal circuits are affected before others, we used Morlet wavelet analysis to obtain high temporal resolution in the time-varying power spectra of local field potentials recorded simultaneously in discrete brain regions at natural sleep onset and during anesthetic-induced loss of righting reflex in rats. Although we observed changes in the local field potentials that were anesthetic-specific, there were some common changes in high-frequency (20–40 Hz) oscillations (reductions in frequency and increases in power) that could be detected at, or before, sleep onset and anesthetic-induced loss of righting reflex. For propofol and natural sleep, these changes occur first in the thalamus before changes could be detected in the neocortex. With dexmedetomidine, the changes occurred simultaneously in the thalamus and neocortex. In addition, the phase relationships between the low-frequency (1–4 Hz) oscillations in thalamic nuclei and neocortical areas are essentially the same for natural sleep and following dexmedetomidine administration, but a sudden change in phase, attributable to an effect in the central medial thalamus, occurs at the point of dexmedetomidine loss of righting reflex. Our data are consistent with the central medial thalamus acting as a key hub through which general anesthesia and natural sleep are initiated. The Journal of Neuroscience, 34 (40) ISSN:0270-6474 ISSN:1529-2401 |
| Databáze: | OpenAIRE |
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