Preeclampsia and gestational hypertension are associated to low maternal circulating kisspeptin levels: a systematic review and meta-analysis

Autor:	Marta Fuentes-Carrasco, Seshadri Reddy Varikasuvu, Ricardo Savirón-Cornudella, María T. López-Baena, Rebeca Ruiz-Román, Faustino R. Pérez-López
Rok vydání:	2021
Předmět:	Gestational hypertension medicine.medical_specialty Kisspeptins business.industry Obstetrics Endocrinology Diabetes and Metabolism Birth weight Diastole Obstetrics and Gynecology medicine.disease Confidence interval female genital diseases and pregnancy complications Preeclampsia Endocrinology Kisspeptin Pre-Eclampsia Pregnancy Meta-analysis embryonic structures Medicine Gestation Humans Female business reproductive and urinary physiology
Zdroj:	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 37(12)
ISSN:	1473-0766
Popis:	BACKGROUND There are contradictory data concerning kisspeptin in gravids with preeclampsia and gestational hypertension (GH). OBJECTIVE To conduct a meta-analysis of studies comparing maternal kisspeptin levels in gravids with and without preeclampsia or GH. MATERIAL AND METHODS We searched PubMed, LILACS, and CNKI list of articles up to 20 August 2021, without language limitations, comparing circulating maternal kisspeptin levels, and maternal and neonatal outcomes in gravids with and without preeclampsia or GH. Meta-analyzed results are reported as standardized mean differences (SMD), and their 95% confidence interval (CI). RESULTS Seven studies with a low-to-moderate risk of bias were eligible for meta-analysis. Gravids with preeclampsia or GH displayed significantly lower circulating kisspeptin levels (SMD, -0.68, 95% CI, -1.04 to -0.32), lower gestational ages at delivery (SMD, -2.22, 95% CI, -3.25 to -1.18), and birth weight (SMD, -2.16, 95% CI, -3.15 to -1.17), and significantly higher body mass indices (MD, 0.56, 95% CI, 0.24-0.88), systolic (SMD, 2.87, 95% CI, 2.22-3.53), and diastolic blood pressures (SMD, 2.57, 95% CI, 2.19-2.95). CONCLUSION Gravids with preeclampsia or GH had lower kisspeptin levels as compared to normotensive controls.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1728aa7c13bf1c843570a45bf56d9297 https://pubmed.ncbi.nlm.nih.gov/34779331 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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