Porous Biodegradable Scaffold: Predetermined Porosity by Dissolution of Poly(ester-anhydride) Fibers from Polyester Matrix
| Autor: | Jukka Seppälä, Laura Elomaa, Harri Korhonen, Risto Hakala, Jaana Rich, Joni Korventausta |
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| Rok vydání: | 2009 |
| Předmět: |
Materials science
Tissue Engineering Tissue Scaffolds Polymers and Plastics Polyesters Biomaterial Bioengineering law.invention Biomaterials chemistry.chemical_compound Synthetic fiber Photopolymer chemistry law Bioactive glass Absorbable Implants Polycaprolactone Materials Chemistry Selective leaching Composite material Porosity Dissolution Biotechnology |
| Zdroj: | Macromolecular Bioscience. 9:654-660 |
| ISSN: | 1616-5195 1616-5187 |
| DOI: | 10.1002/mabi.200800306 |
| Popis: | A novel selective leaching method for the porogenization of the biodegradable scaffolds was developed. Continuous, predetermined pore structure was prepared by dissolving fast eroding poly(epsilon-caprolactone)-based poly(ester-anhydride) fibers from the photo-crosslinked poly(epsilon-caprolactone) matrix. The porogen fibers dissolved in the phosphate buffer (pH 7.4, 37 degrees C) within a week, resulting in the porosity that replicated exactly the single fiber dimensions and the overall arrangement of the fibers. The amount of the porosity, estimated with micro-CT, corresponded with the initial amount of the fibers. The potential to include bioactive agents in the porogen fibers was demonstrated with the bioactive glass. |
| Databáze: | OpenAIRE |
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