Architecture of a catalytically active homotrimeric plant cellulose synthase complex
| Autor: | Jochen Zimmer, Pallinti Purushotham, Ruoya Ho |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine Supramolecular chemistry engineering.material 01 natural sciences Cell wall 03 medical and health sciences chemistry.chemical_compound Multienzyme Complexes Catalytic Domain Cellulose synthase complex Cellulose Plant Proteins Multidisciplinary ATP synthase biology Transmembrane protein Cellulose microfibril 030104 developmental biology Populus chemistry Glucosyltransferases Biophysics engineering biology.protein Biocatalysis Biopolymer Protein Multimerization 010606 plant biology & botany |
| Zdroj: | Science (New York, N.Y.). 369(6507) |
| ISSN: | 1095-9203 |
| Popis: | Plant cell wall construction crew Plants produce a complex cell wall in which cellulose, a glucose polymer, is a major component. Cellulose fibers are formed from close-packed single chains of cellulose that have been proposed to be formed by multimeric complexes (18 or more subunits) of the enzyme cellulose synthase, which exists in several isoforms. Purushotham et al. determined a cryo–electron microscopy structure of a trimer of a single isoform of cellulose synthase. A large channel forms a path for cellulose chains through the membrane-embedded complex. The structure also reveals oligomeric interfaces and provides a framework for modeling the larger complexes seen in plant membranes. The close arrangement of exit sites for nascent glycan chains is consistent with the enzyme complex playing a role in directing cellulose microfibril formation. Science , this issue p. 1089 |
| Databáze: | OpenAIRE |
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