Utility of CD99 Paranuclear Expression in the Differential Diagnosis of Merkel Cell Carcinoma
| Autor: | Leonardo S. Lino-Silva, Claudia Haydee Sarai Caro-Sánchez, Dmitry V. Kazakov, Michal Michal, Hugo Dominguez-Malagon |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty Skin Neoplasms CD99 Biology 12E7 Antigen Pathology and Forensic Medicine Diagnosis Differential 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Biomarkers Tumor Humans Merkel cell carcinoma food and beverages medicine.disease Immunohistochemistry Staining Carcinoma Merkel Cell medicine.anatomical_structure 030220 oncology & carcinogenesis Surgery Anatomy Differential diagnosis Pancreas |
| Zdroj: | International journal of surgical pathology. 24(4) |
| ISSN: | 1940-2465 |
| Popis: | Background. Recent reviews have referred to the paranuclear dot-like staining pattern of CD99 in several neoplasms, including solid pseudopapillary tumors in the pancreas, colonic adenocarcinomas, and colonic adenomas as well as in Merkel cell carcinoma (MCC). The aim of this work was to explore the utility of CD99 paranuclear staining in the differential diagnosis of MCC. Material and Methods. We explore paranuclear dot-like CD99 expression in several small, round blue cell neoplasms, including neuroendocrine neoplasms, Ewing sarcomas/primitive neuroectodermal tumors (EWS/PNET), melanomas, small cell lung carcinomas (SCC), lymphoblastic lymphoma/leukemia, and rhabdomyosarcomas, in comparison with 33 cases of MCC, to determine the specificity of the paranuclear dot-like CD99 expression in MCC. Results. Twenty MCC (60%) demonstrated focal expression of CD99 and of those, 14 (42.4%) showed the characteristic paranuclear dot-like expression. CD99 was also paranuclear positive in 4 of 11 (36%) SCC, in 3 of 7 (43%) EWS/PNET, in 1 of 6 (16%) lymphoblastic lymphoma/leukemia cases, in 3 of 3 (100%) rhabdomyosarcomas and all melanomas were negative for the CD99 reaction. Conclusion. CD99 paranuclear dot-like expression was not exclusive of the MCC compared with several neoplasms included in its differential diagnosis. This expression is not a great diagnostic aid. |
| Databáze: | OpenAIRE |
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