High clearance continuous renal replacement therapy with a modified dialysis machine
| Autor: | Christian Schlaeper, Markus Manns, Nathan W. Levin, Richard Amerling |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Metabolic Clearance Rate medicine.medical_treatment Bicarbonate slow continuous dialysis urea clearance Urology Dialysate flow CRRT acute renal failure chemistry.chemical_compound Renal Dialysis medicine Humans Renal replacement therapy Dialysis Urea clearance business.industry dialysis dose Blood flow Acute Kidney Injury Surgery Renal Replacement Therapy Ultrafiltration (renal) chemistry Nephrology Hemodialysis business |
| Zdroj: | Kidney International. 56:S20-S23 |
| ISSN: | 0085-2538 |
| Popis: | High clearance continuous renal replacement therapy with a modified dialysis machine. Recent studies suggest that the dialysis dose significantly affects survival in acute renal failure (ARF) patients and that bicarbonate dialysate improves acid-base balance during continuous renal replacement therapy (CRRT). These data inspired us to use slow continuous dialysis (SCD) in the treatment of ARF. SCD is defined by the following parameters: (a) blood flow (QB) = 100 to 200 ml/min, (b) dialysate flow (QD) = 100 to 300 ml/min, (c) the use of a modified hemodialysis machine with controlled ultrafiltration and online production of bicarbonate-based dialysate, and (d) continuous or extended daily treatment for 8 to 24 hours. SCD provides a urea clearance in the 70 to 80 ml/min range. Preliminary data from an ongoing clinical trial demonstrate the safety, efficiency, and simplicity of the treatment. |
| Databáze: | OpenAIRE |
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