Active multilayered capsules for in vivo bone formation
| Autor: | Carlos Mendoza-Palomares, Christina Cortez, N. Messadeq, Angus P. R. Johnston, Nadia Benkirane-Jessel, Jean-Claude Voegel, Didier Mainard, Sybille Facca, Frank Caruso, Andrée Dierich |
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| Rok vydání: | 2010 |
| Předmět: |
Cellular differentiation
Bone Morphogenetic Protein 2 Capsules Bone morphogenetic protein 2 Cell Line Mice Tissue engineering In vivo Osteogenesis Bone cell Animals Regeneration Polylysine Embryonic Stem Cells Multidisciplinary Osteoblasts Tissue Engineering Chemistry Regeneration (biology) Cell Differentiation Transforming Growth Factor alpha Biological Sciences Embryonic stem cell Cell biology Polyglutamic Acid Immunology Stem cell |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 107(8) |
| ISSN: | 1091-6490 |
| Popis: | Interest in the development of new sources of transplantable materials for the treatment of injury or disease has led to the convergence of tissue engineering with stem cell technology. Bone and joint disorders are expected to benefit from this new technology because of the low self-regenerating capacity of bone matrix secreting cells. Herein, the differentiation of stem cells to bone cells using active multilayered capsules is presented. The capsules are composed of poly-L-glutamic acid and poly-L-lysine with active growth factors embedded into the multilayered film. The bone induction from these active capsules incubated with embryonic stem cells was demonstrated in vitro. Herein, we report the unique demonstration of a multilayered capsule-based delivery system for inducing bone formation in vivo. This strategy is an alternative approach for in vivo bone formation. Strategies using simple chemistry to control complex biological processes would be particularly powerful, as they make production of therapeutic materials simpler and more easily controlled. |
| Databáze: | OpenAIRE |
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