Neoadjuvant Chemotherapy for Osteosarcoma of the Extremity
| Autor: | Elisabetta Setola, Davide Maria Donati, Franco Bertoni, Cristiana Forni, Michela Versari, Gaetano Bacci, Rodolfo Capanna, Stefano Ferrari, Mario Mercuri, Gabriella Bernini, Antonio Briccoli, Alessandra Longhi |
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| Přispěvatelé: | Bacci G., Forni C., Ferrari S., Longhi A., Bertoni F., Mercuri M., Donati D., Capanna R., Bernini G., Briccoli A., Setola E., Versari M. |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.drug_class medicine.medical_treatment Bone Neoplasms Bone Neoplasm Antimetabolite Disease-Free Survival medicine Humans Doxorubicin Aged Cisplatin Osteosarcoma Chemotherapy Ifosfamide business.industry Extremities Hematology Middle Aged medicine.disease Primary tumor Surgery Treatment Outcome Oncology Chemotherapy Adjuvant Pediatrics Perinatology and Child Health Patient Compliance Female Methotrexate Radiology business Extremitie Human medicine.drug |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 25:845-853 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/00043426-200311000-00006 |
| Popis: | Purpose: The aim of this study was to compare the results in terms of histologic response to primary chemotherapy of two sequential studies in osteosarcoma patients preoperatively treated with methotrexate, doxorubicin, cisplatin, and ifosfamide, given at different doses Patients and Methods: Between January 1993 and March 1995, 171 patients with osteosarcoma of the extremity were treated according to a protocol of neoadjuvant chemotherapy with preoperative methotrexate, cisplatin, doxorubicin, and ifosfamide. From April 1995 to December 1999, 196 osteosarcoma patients were preoperatively treated with the same drugs at higher doses. Postoperatively, patients received the same treatment in both studies used, but poor responders (tumor necrosis |
| Databáze: | OpenAIRE |
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