Antifungal innate immunity: recognition and inflammatory networks

Autor: Jessica Quintin, Daniela C. Ifrim, Mihai G. Netea, Frank L. van de Veerdonk, Katharina L. Becker
Přispěvatelé: Radboud University Medical Center [Nijmegen]
Rok vydání: 2014
Předmět:
MESH: Fungi
[SDV]Life Sciences [q-bio]
Immunology
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
Candida glabrata
[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity
Proinflammatory cytokine
Microbiology
MESH: Receptors
Pattern Recognition
Immune system
Signature-tagged mutagenesis
MESH: Mycoses
Immunity
Flora (microbiology)
Immunology and Allergy
MESH: Protein Binding
Animals
Humans
MESH: Animals
Candida albicans
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Alternative infection models
Innate immune system
MESH: Humans
MESH: Immune System
biology
Host (biology)
MESH: Host-Pathogen Interactions
Pattern recognition receptor
Fungi
biology.organism_classification
Immunity
Innate
Mutant library
Drosophila melanogaster
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Mycoses
Immune System
Receptors
Pattern Recognition
Host-Pathogen Interactions
[SDV.IMM]Life Sciences [q-bio]/Immunology
Fungal virulence factors
MESH: Immunity
Innate
Protein Binding
Zdroj: Seminars in Immunopathology, 37, 2, pp. 107-16
Seminars in Immunopathology, 37, 107-16
Seminars in Immunopathology
Seminars in Immunopathology, Springer Verlag, 2015, 37 (2), pp.107-116. ⟨10.1007/s00281-014-0467-z⟩
ISSN: 1863-2300
1863-2297
DOI: 10.1007/s00281-014-0467-z⟩
Popis: Contains fulltext : 154433.pdf (Publisher’s version ) (Closed access) A large variety of fungi are present in the environment, among which a proportion colonizes the human body, usually without causing any harm. However, depending on the host immune status, commensals can become opportunistic pathogens that induce diseases ranging from superficial non-harmful infection to life-threatening systemic disease. The interplay between the host and the fungal commensal flora is being orchestrated by an efficient recognition of the microorganisms, which in turn ensures a proper balance between tolerance of the normal fungal flora and induction of immune defense mechanisms when invasion occurs. Pattern recognition receptors (PRRs) play a significant role in maintaining this balance due to their capacity to sense fungi and induce host responses such as the induction of proinflammatory cytokines involved in the activation of innate and adaptive immune responses. In the present review, we will discuss the most recent findings regarding the recognition of Candida albicans and Aspergillus fumigatus and the different types of immune cells that play a role in antifungal host defense.
Databáze: OpenAIRE
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