A Novel Type of Selective Immunoglobulin M Deficiency in a Patient with Autoimmune Liver Cirrhosis with Recurrent Hepatocellular Carcinoma: A Case Report and Review of the Literature
| Autor: | Kazuto Tajiri, Yukihiro Shimizu, Koichi Tsuneyama, Kazuhiro Nomoto, Shinji Minami, Masahisa Arahata |
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| Rok vydání: | 2012 |
| Předmět: |
Liver Cirrhosis
Carcinoma Hepatocellular Cirrhosis Biopsy Immunology Autoimmune hepatitis Humans Immunology and Allergy Medicine IgM deficiency medicine.diagnostic_test business.industry Liver Neoplasms General Medicine Gene rearrangement Middle Aged medicine.disease Immunoglobulin Class Switching Immunohistochemistry Immunoglobulin M Immunoglobulin class switching Liver biopsy Hepatocellular carcinoma Female business Liver cancer |
| Zdroj: | International Archives of Allergy and Immunology. 161:91-96 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000343583 |
| Popis: | A 64-year-old female with advanced liver cirrhosis who had never experienced severe infections presented in 2004 with general malaise. At the time, her serum showed low levels of immunoglobulin (Ig) M (11 mg/dl) with high levels of both IgG (2,942 mg/dl) and IgA (808 mg/dl). Because serum levels of IgG and IgA in previous cases of selective IgM deficiency were normal, this case could have a novel immunological mechanism. By 2006, serum IgM was undetectable ( |
| Databáze: | OpenAIRE |
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