Artemisinin and its derivatives
| Autor: | Jonathan W Wong, James C.G. Doery, Robert C Griffin, Xinxin Long, Nelson Siukei Lam |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Angiogenesis Cell Artemisia annua Apoptosis Biology 03 medical and health sciences 0302 clinical medicine Cell Line Tumor medicine Animals Humans Pharmacology (medical) Antimalarial Agent Artemisinin Pharmacology Leukemia Cancer medicine.disease biology.organism_classification Xenograft Model Antitumor Assays Artemisinins 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Signal transduction Reactive Oxygen Species medicine.drug |
| Zdroj: | Anti-Cancer Drugs. 30:1-18 |
| ISSN: | 0959-4973 |
| DOI: | 10.1097/cad.0000000000000697 |
| Popis: | Artemisinin (ART) and its derivatives are one of the most important classes of antimalarial agents, originally derived from a Chinese medicinal plant called Artemisia annua L. Beyond their outstanding antimalarial and antischistosomal activities, ART and its derivatives also possess both in-vitro and in-vivo activities against various types of cancer. Their anticancer effects range from initiation of apoptotic cell death to inhibition of cancer proliferation, metastasis and angiogenesis, and even modulation of the cell signal transduction pathway. This review provides a comprehensive update on ART and its derivatives, their mechanisms of action, and their synergistic effects with other chemicals in targeting leukemia cells. Combined with limited evidence of drug resistance and low toxicity profile, we conclude that ART and its derivatives, including dimers, trimers, and hybrids, might be a potential therapeutic alternative to current chemotherapies in combating leukemia, although more studies are necessary before they can be applied clinically. |
| Databáze: | OpenAIRE |
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