Potential involvement of chondroitin sulfate A in the pathogenesis of ameloblastoma
| Autor: | Hiroshi Kurita, Xiangjun Li, Kyou Iijima, Jun Nakayama, Tiepeng Xiao, Kenji Kurashina |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Histology Adolescent Keratan sulfate Ameloblastoma Extracellular matrix 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Stroma medicine Humans Keratocyst Child Aged Aged 80 and over Chondroitin Sulfates Antibodies Monoclonal Cell Differentiation Cell Biology General Medicine Heparan sulfate Middle Aged medicine.disease Immunohistochemistry Dentigerous cyst Gene Expression Regulation Neoplastic 030104 developmental biology chemistry 030220 oncology & carcinogenesis Female medicine.symptom |
| Zdroj: | Acta Histochemica. 119:439-445 |
| ISSN: | 0065-1281 |
| DOI: | 10.1016/j.acthis.2017.04.001 |
| Popis: | Ameloblastoma is classified as a benign odontogenic tumor characterized by locally invasive behavior and high risk of recurrence. Here, we evaluate a potential role for glycosaminoglycan, a structural component of cell membranes and extracellular matrix, in ameloblstoma pathogenesis. We subjected formalin-fixed, paraffin-embedded tissue sections of 34 cases of ameloblastoma, 10 of odontogenic keratocyst, and 17 of dentigerous cyst to immunohistochemistry using monoclonal antibodies recognizing chondroitin sulfate A (CS-A), heparan sulfate (HS), and keratan sulfate (KS). Expression levels of CS-A in epithelial component and stroma of ameloblastoma were significantly higher than those in odontogenic keratocyst and dentigerous cyst. Moreover, CS-A in ameloblastoma was more strongly expressed in stellate reticulum-like cells than in amelobast-like cells with statistical significance. On the other hand, expression levels of HS and KS in epithelial component and stroma of ameloblastoma were lower compared with CS-A. These results overall reveal that among these odontogenic lesions, CS-A is preferentially expessed in ameloblastoma, suggesting potential pathogenetic role probably in cytodifferention of tumor cells to stellate reticulum-like cells. |
| Databáze: | OpenAIRE |
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