Association of Single-Nucleotide Polymorphisms inIL28B,but NotTNF-α,With Severity of Disease Caused by Andes Virus
| Autor: | Lilian Vera, Natalia Echeverría-Chagas, Karla Pino, Eliecer Villagra, Claudia Marco, Marcela Ferrés, Natalia Lagos, Jenniffer Angulo, Janepsy Díaz, Marcelo López-Lastra, Constanza Martínez-Valdebenito, Judith Mora, Natalia Becerra, Juan Francisco Miquel, Héctor Galeno, Andrea Bermúdez, Marcela Cárcamo |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Microbiology (medical) Orthohantavirus Adolescent Genotyping Techniques viruses Hantavirus Infections education Andes virus Single-nucleotide polymorphism Polymorphism Single Nucleotide Severity of Illness Index Electronic Articles Pathogenesis Loss of heterozygosity Young Adult Humans Medicine SNP Chile Allele Child Genetic Association Studies Aged Aged 80 and over Tumor Necrosis Factor-alpha business.industry Interleukins Infant Newborn Case-control study Infant Middle Aged Infectious Diseases Case-Control Studies Child Preschool Immunology Female Interferons business |
| Zdroj: | Clin infect Dis. Artículos CONICYT CONICYT Chile instacron:CONICYT |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/civ830 |
| Popis: | Background Andes virus (ANDV) is the sole etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in Chile, with a fatality rate of about 35%. Individual host factors affecting ANDV infection outcome are poorly understood. In this case-control genetic association analysis, we explored the link between single-nucleotide polymorphisms (SNPs) rs12979860, rs8099917 and rs1800629 and the clinical outcome of ANDV-induced disease. The SNPs rs12979860 and rs8099917 are known to play a role in the differential expression of the interleukin 28B gene (IL28B), whereas SNP rs1800629 is implicated in the expression of tumor necrosis factor α gene (TNF-α). Methods A total of 238 samples from confirmed ANDV-infected patients collected between 2006 and 2014, and categorized according to the severity of the disease, were genotyped for SNPs rs12979860, rs8099917, and rs1800629. Results Analysis of IL28B SNPs rs12979860 and rs8099917 revealed a link between homozygosity of the minor alleles (TT and GG, respectively), displaying a mild disease progression, whereas heterozygosity or homozygosity for the major alleles (CT/CC and TG/TT, respectively) in both IL28B SNPs is associated with severe disease. No association with the clinical outcome of HCPS was observed for TNF-α SNP rs1800629 (TNF -308G>A). Conclusions The IL28B SNPs rs12979860 and rs8099917, but not TNF-α SNP rs1800629, are associated with the clinical outcome of ANDV-induced disease, suggesting a possible link between IL28B expression and ANDV pathogenesis. |
| Databáze: | OpenAIRE |
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