Modelling Human Channelopathies Using Induced Pluripotent Stem Cells: A Comprehensive Review

Autor:	Thomas Seufferlein, Martin Müller, Anett Illing, Jörg Homann
Rok vydání:	2013
Předmět:	lcsh:Internal medicine Somatic cell business.industry Long QT syndrome Cardiac arrhythmia Review Article Cell Biology Disease Bioinformatics medicine.disease Regenerative medicine medicine lcsh:RC31-1245 business Induced pluripotent stem cell Molecular Biology Reprogramming Cardiac channelopathy
Zdroj:	Stem Cells International Stem Cells International, Vol 2013 (2013)
ISSN:	1687-9678 1687-966X
DOI:	10.1155/2013/496501
Popis:	The generation of induced pluripotent stem cells (iPS cells) has pioneered the field of regenerative medicine and developmental biology. They can be generated by overexpression of a defined set of transcription factors in somatic cells derived from easily accessible tissues such as skin or plucked hair or even human urine. In case of applying this tool to patients who are classified into a disease group, it enables the generation of a disease- and patient-specific research platform. iPS cells have proven a significant tool to elucidate pathophysiological mechanisms in various diseases such as diabetes, blood disorders, defined neurological disorders, and genetic liver disease. One of the first successfully modelled human diseases was long QT syndrome, an inherited cardiac channelopathy which causes potentially fatal cardiac arrhythmia. This review summarizes the efforts of reprogramming various types of long QT syndrome and discusses the potential underlying mechanisms and their application.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166ce9ecf3babc5e9a56b181dae010ee https://doi.org/10.1155/2013/496501 Zobrazit plný text záznamu Plný text ve formátu PDF